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<blockquote data-quote="phoenix" data-source="post: 1017613" data-attributes="member: 12578"><p>"Circulating FFA" means plasma triglycerides" Um they aren't trigs when they are 'free'</p><p></p><p>All dietary and body fats are triglycerides(triacylglycerols) they are three fatty acids joined to a glycerol backbone. The bond that joins them to the backbone is called an ester bond. They are large molecules and as fat and water don't 'mix' they can't be transported in the watery environment of the blood and lymph They need 'containers' to allow them to move around. They are carried in lipoproteins</p><p>(chylomicrons, very low density lipoproteins , low density lipoproteins and high density lipoproteins.</p><p></p><p>Free fatty acids are otherwise known as non esterified fatty acids ie the triglyceride has been broken down and the fatty acids are no longer attached to the backbone. This occurs at several points in the process of digestion and transport . (ie trigs are broken down and afterward reformed )One of these is when stored fat is broken down and released into the blood in the 'fasting' period .These free fatty acids are smaller and can be carried in the blood together with albumin (a protein).</p><p>There are two fairly easy Khan videos that explain it.</p><p>[MEDIA=youtube]i0kHf_5s3J8[/MEDIA]</p><p>[MEDIA=youtube]u5VmmOji1ho[/MEDIA]</p><p></p><p>The role of high levels of free fatty acids in increasing insulin resistance is discussed in the not so easy paper which was cited in the Wolpert paper mentioned above <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995548/" target="_blank">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995548/</a></p></blockquote><p></p>
[QUOTE="phoenix, post: 1017613, member: 12578"] "Circulating FFA" means plasma triglycerides" Um they aren't trigs when they are 'free' All dietary and body fats are triglycerides(triacylglycerols) they are three fatty acids joined to a glycerol backbone. The bond that joins them to the backbone is called an ester bond. They are large molecules and as fat and water don't 'mix' they can't be transported in the watery environment of the blood and lymph They need 'containers' to allow them to move around. They are carried in lipoproteins (chylomicrons, very low density lipoproteins , low density lipoproteins and high density lipoproteins. Free fatty acids are otherwise known as non esterified fatty acids ie the triglyceride has been broken down and the fatty acids are no longer attached to the backbone. This occurs at several points in the process of digestion and transport . (ie trigs are broken down and afterward reformed )One of these is when stored fat is broken down and released into the blood in the 'fasting' period .These free fatty acids are smaller and can be carried in the blood together with albumin (a protein). There are two fairly easy Khan videos that explain it. [MEDIA=youtube]i0kHf_5s3J8[/MEDIA] [MEDIA=youtube]u5VmmOji1ho[/MEDIA] The role of high levels of free fatty acids in increasing insulin resistance is discussed in the not so easy paper which was cited in the Wolpert paper mentioned above [URL]http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995548/[/URL] [/QUOTE]
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