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<blockquote data-quote="Winnie53" data-source="post: 1178442" data-attributes="member: 160246"><p>From the book, <strong>Drug Muggers: Which Medications Are Robbing Your Body of Essential Nutrients--And Natural Ways to Restore Them by Suzy Cohen, RPh</strong>...</p><p></p><p><em>"Leg cramps, muscle spasms, memory loss, and fatigue: An of these conditions may develop from a deficiency of CoQ10 (ubiquinone). This life sustaining antioxidant gets demolished by hundreds of medications, including statin cholesterol drugs, metformin, antidepressants, beta blockers, and diuretics." </em>(page 9)</p><p></p><p><strong>From this website</strong> - ( <a href="http://nutritionreview.org/2013/04/practical-guide-avoiding-drug-induced-nutrient-depletion/" target="_blank">http://nutritionreview.org/2013/04/practical-guide-avoiding-drug-induced-nutrient-depletion/</a> )...</p><p></p><p><span style="font-size: 15px"><strong><strong><em>"Oral Hypoglycemics</em></strong></strong></span></p><p><em>Metformin (Glucophage, Glucophage XR and Glucovance) enhances the action of insulin in cases of insulin resistance, allowing glucose to enter the cells. This reduces elevated blood sugar. A study published in the Archives of Internal Medicine showed that diabetics on metformin had B12 levels that were less than half those of control subjects. The longer the drug had been used and the higher the dose, the greater the drop in B12. (16)</em></p><p><em></em></p><p><em>In people with Type 2 diabetes who take metformin therapy, serum folic acid levels decrease 7 percent and vitamin B12 levels decrease by 14 percent. (17) B12 and folic acid depletion also increases homocysteine levels. In addition, metformin may deplete CoQ10, thereby increasing heart disease risk. To reduce these effects, patients should take vitamin B12 (800 mcg), folic acid (400 mcg) and CoQ10 (100 mg daily)."</em></p><p><em></em></p><p><strong>And here's something else to think about, "What vitamins and minerals are depleted by diabetes?"</strong></p><p></p><p>This online article by an orthopedic surgeon says, vitamin B12, vitamin D, vitamin E, and magnesium which is what I use for leg cramps, magnesium citrate 450-600 mg/day, but I'd start at 200-300 mg/day; (<em>"Other forms of magnesium, such as magnesium glycinate or taurate, tend to be milder on your intestines and may be more appropriate for people who are not suffering for constipation." - Alissa Segerstein and Tom Malterre, MS, CN, The Elimination Diet, 2015</em>)...</p><p></p><p><strong>Vitamin Deficiencies in People with Diabetes: The Supplements You Need by Mark S. Stevens</strong></p><p><strong>April 28, 2012</strong></p><p></p><p>Click on this link to read Dr. Steven's article on supplements he uses with patients <a href="https://www.diabeteshealth.com/vitamin-deficiencies-in-people-with-diabetes-the-supplements-you-need/" target="_blank">https://www.diabeteshealth.com/vitamin-deficiencies-in-people-with-diabetes-the-supplements-you-need/</a></p><p></p><p><strong>Read what others here posted about Metformin and leg cramps a few years ago... </strong><a href="http://www.diabetes.co.uk/forum/threads/leg-cramps-metformin.32630/" target="_blank">http://www.diabetes.co.uk/forum/threads/leg-cramps-metformin.32630/</a></p><p></p><p>I'm assuming your doctor checked your <strong>lactic acid levels</strong> to rule that out. While looking around the internet I saw lots of complaints about metformin and muscle cramps. You're not alone. Hope this helps. <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /></p></blockquote><p></p>
[QUOTE="Winnie53, post: 1178442, member: 160246"] From the book, [B]Drug Muggers: Which Medications Are Robbing Your Body of Essential Nutrients--And Natural Ways to Restore Them by Suzy Cohen, RPh[/B]... [I]"Leg cramps, muscle spasms, memory loss, and fatigue: An of these conditions may develop from a deficiency of CoQ10 (ubiquinone). This life sustaining antioxidant gets demolished by hundreds of medications, including statin cholesterol drugs, metformin, antidepressants, beta blockers, and diuretics." [/I](page 9) [B]From this website[/B] - ( [URL]http://nutritionreview.org/2013/04/practical-guide-avoiding-drug-induced-nutrient-depletion/[/URL] )... [SIZE=4][B][B][I]"Oral Hypoglycemics[/I][/B][/B][/SIZE] [I]Metformin (Glucophage, Glucophage XR and Glucovance) enhances the action of insulin in cases of insulin resistance, allowing glucose to enter the cells. This reduces elevated blood sugar. A study published in the Archives of Internal Medicine showed that diabetics on metformin had B12 levels that were less than half those of control subjects. The longer the drug had been used and the higher the dose, the greater the drop in B12. (16) In people with Type 2 diabetes who take metformin therapy, serum folic acid levels decrease 7 percent and vitamin B12 levels decrease by 14 percent. (17) B12 and folic acid depletion also increases homocysteine levels. In addition, metformin may deplete CoQ10, thereby increasing heart disease risk. To reduce these effects, patients should take vitamin B12 (800 mcg), folic acid (400 mcg) and CoQ10 (100 mg daily)." [/I] [B]And here's something else to think about, "What vitamins and minerals are depleted by diabetes?"[/B] This online article by an orthopedic surgeon says, vitamin B12, vitamin D, vitamin E, and magnesium which is what I use for leg cramps, magnesium citrate 450-600 mg/day, but I'd start at 200-300 mg/day; ([I]"Other forms of magnesium, such as magnesium glycinate or taurate, tend to be milder on your intestines and may be more appropriate for people who are not suffering for constipation." - Alissa Segerstein and Tom Malterre, MS, CN, The Elimination Diet, 2015[/I])... [B]Vitamin Deficiencies in People with Diabetes: The Supplements You Need by Mark S. Stevens April 28, 2012[/B] Click on this link to read Dr. Steven's article on supplements he uses with patients [URL]https://www.diabeteshealth.com/vitamin-deficiencies-in-people-with-diabetes-the-supplements-you-need/[/URL] [B]Read what others here posted about Metformin and leg cramps a few years ago... [/B][URL]http://www.diabetes.co.uk/forum/threads/leg-cramps-metformin.32630/[/URL] I'm assuming your doctor checked your [B]lactic acid levels[/B] to rule that out. While looking around the internet I saw lots of complaints about metformin and muscle cramps. You're not alone. Hope this helps. :) [/QUOTE]
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