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SGLT2 inhibitors: updated advice on the risk of diabetic ketoacidosis
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<blockquote data-quote="Oldvatr" data-source="post: 1517593" data-attributes="member: 196898"><p>Firstly you appear to accept the hypothesis that IR can only be 'cured' by LC+IF. The science has not yet proven this and the jury is still out in this. Secondly SGLT-2 Inhibitors are being prescribed for Insulin Dependants as well as T2D, so high insulin is controllable in their case. What you describe is the status quo that is the lot for most diabetics suffering this progressive disease (???) and yes, we could default back to this if LC+IF does not work. What does this have to do with SGLT-2 Inhibitors? If they work well then the sugar goes down the drain [literally], and we will be ok. My OP was to show that this particular path seems to carry a certain amount of risk that users need to be made aware of, as well as HCP's. </p><p></p><p>Keeping well hydrated may be the key to keeping the DKA monster in check, and is good advice for people taking these meds. I hope it is as simple as that, and then all we will contend with is UTI and possible AKI as a follow on. There are a few others such as pancreitis and bladder cancer, with the occasional broken bone to wake us up to the apparent fact that these meds are not as safe as NICE and the manufacturers would have us believe. Why can't we incorporate FDA warnings into the UK care system? Why are drugs that are prescribed daily in the UK banned or severely restricted in US? I am thinking of Actos, and thalidomide for starters.</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 1517593, member: 196898"] Firstly you appear to accept the hypothesis that IR can only be 'cured' by LC+IF. The science has not yet proven this and the jury is still out in this. Secondly SGLT-2 Inhibitors are being prescribed for Insulin Dependants as well as T2D, so high insulin is controllable in their case. What you describe is the status quo that is the lot for most diabetics suffering this progressive disease (???) and yes, we could default back to this if LC+IF does not work. What does this have to do with SGLT-2 Inhibitors? If they work well then the sugar goes down the drain [literally], and we will be ok. My OP was to show that this particular path seems to carry a certain amount of risk that users need to be made aware of, as well as HCP's. Keeping well hydrated may be the key to keeping the DKA monster in check, and is good advice for people taking these meds. I hope it is as simple as that, and then all we will contend with is UTI and possible AKI as a follow on. There are a few others such as pancreitis and bladder cancer, with the occasional broken bone to wake us up to the apparent fact that these meds are not as safe as NICE and the manufacturers would have us believe. Why can't we incorporate FDA warnings into the UK care system? Why are drugs that are prescribed daily in the UK banned or severely restricted in US? I am thinking of Actos, and thalidomide for starters. [/QUOTE]
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SGLT2 inhibitors: updated advice on the risk of diabetic ketoacidosis
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