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SGLT2 inhibitors: updated advice on the risk of diabetic ketoacidosis
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<blockquote data-quote="Oldvatr" data-source="post: 1731637" data-attributes="member: 196898"><p>One of the bonus points for these drugs was that their operation was supposed to be self regulating, i.e. they dropped bgl by extracting glucose via the kidneys, but did not operate when bgl is below 'normal' levels. They were supposed to be safe because of this, so it is not clear what the mechanism causing DKA is. Unlikely to be insulin dropping off the scale if the reports of DKA happening with bgl still in the 7-10 mmol/l range are true. There must be something else happening instead.</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 1731637, member: 196898"] One of the bonus points for these drugs was that their operation was supposed to be self regulating, i.e. they dropped bgl by extracting glucose via the kidneys, but did not operate when bgl is below 'normal' levels. They were supposed to be safe because of this, so it is not clear what the mechanism causing DKA is. Unlikely to be insulin dropping off the scale if the reports of DKA happening with bgl still in the 7-10 mmol/l range are true. There must be something else happening instead. [/QUOTE]
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SGLT2 inhibitors: updated advice on the risk of diabetic ketoacidosis
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