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SGLT2 inhibitors: updated advice on the risk of diabetic ketoacidosis
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<blockquote data-quote="Oldvatr" data-source="post: 2313122" data-attributes="member: 196898"><p>I have not seen any defnite evidence that LC diets are harmful when used with SGLT2. The only proper evidence I found is:</p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971428/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971428/</a></p><p></p><p>Note that the patient was starting a "very strict LC diet" and was only 6 days into the diet when the event occurred. The important thing I note from this study is that the patient was actually a Type 1 diabetic, so the SGLT2 medicine was not appropriate anyway.</p><p></p><p>There have been other reports that link SGLT2 euDKA events with T1D as shown by FDA advisories, but it seems to be the SGLT2 inhibitor that induces the DKA, not the low carb. </p><p></p><p>The other point is that LC diets lower BGL as does the SGLT2 inhinbitors in parallel. So it may become necessary to adjust the medication dose as the LC diet takes control. This is normal for any bgl lowering medication used during Low Carb (speaking as a T2) but can apply to insulin doses too, but under medical supervision</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 2313122, member: 196898"] I have not seen any defnite evidence that LC diets are harmful when used with SGLT2. The only proper evidence I found is: [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971428/[/URL] Note that the patient was starting a "very strict LC diet" and was only 6 days into the diet when the event occurred. The important thing I note from this study is that the patient was actually a Type 1 diabetic, so the SGLT2 medicine was not appropriate anyway. There have been other reports that link SGLT2 euDKA events with T1D as shown by FDA advisories, but it seems to be the SGLT2 inhibitor that induces the DKA, not the low carb. The other point is that LC diets lower BGL as does the SGLT2 inhinbitors in parallel. So it may become necessary to adjust the medication dose as the LC diet takes control. This is normal for any bgl lowering medication used during Low Carb (speaking as a T2) but can apply to insulin doses too, but under medical supervision [/QUOTE]
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SGLT2 inhibitors: updated advice on the risk of diabetic ketoacidosis
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