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SGLT2 inhibitors: updated advice on the risk of diabetic ketoacidosis
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<blockquote data-quote="Oldvatr" data-source="post: 2313251" data-attributes="member: 196898"><p>Thank you for that. Glic is fairly benign and has some heart and CVD benefits like Metforin, but there are a few things to be aware before discussing it with Doc. It is a Sylphonylurea drug, and the early onse gainrd a reputaio for caning th pancreas possibly leading to burnout. Glic is a modern update on the drug family, and so far it seems it does not give that problem, but is the only one in the family that has the brownie point. This came out in my discussion in the Hospital where I was able to find evidence in support. Mu consultant found the same report unaided by me, which pleased them no end, so there was no further arguments on that score. Nonetheless, I would suggest keeping it to a lowish dose, which Low Carb will help with.</p><p></p><p>Secondly, Glic is listed by DVLA as a drug that can drive you to hypoland and back, so they need you to check you sugars before engaging gear. In fact, the Docs should be able to support you self testing and supply test strips on scrip to meet this requirement. My GP does. Keep a log of bgl test results and show it to them at review time to show you are getting good low results. (assuming you do, that is)</p><p></p><p>I am happy with Glic with Metformin as it allows me to have a lowish carb diet without needing keto, and I can eat some small amounts of carby treats without blowing the bank. My HbA1c over the last 4 years have all come in around 42 or 44 and LC is one lifestyle I can maintain without too much sweat or angst.</p><p></p><p>Lastly, the hypos from Glic when they occur tend to be fairly mild and short lived providing you are producing your own internal insulin (you would not be on Glic if you weren't, anyway) Glic has a short half life of about an hour, then your liver should have compensated by upping the glucose again. But I find my 40mg tab can drop my bgl by about 4 mmol/l</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 2313251, member: 196898"] Thank you for that. Glic is fairly benign and has some heart and CVD benefits like Metforin, but there are a few things to be aware before discussing it with Doc. It is a Sylphonylurea drug, and the early onse gainrd a reputaio for caning th pancreas possibly leading to burnout. Glic is a modern update on the drug family, and so far it seems it does not give that problem, but is the only one in the family that has the brownie point. This came out in my discussion in the Hospital where I was able to find evidence in support. Mu consultant found the same report unaided by me, which pleased them no end, so there was no further arguments on that score. Nonetheless, I would suggest keeping it to a lowish dose, which Low Carb will help with. Secondly, Glic is listed by DVLA as a drug that can drive you to hypoland and back, so they need you to check you sugars before engaging gear. In fact, the Docs should be able to support you self testing and supply test strips on scrip to meet this requirement. My GP does. Keep a log of bgl test results and show it to them at review time to show you are getting good low results. (assuming you do, that is) I am happy with Glic with Metformin as it allows me to have a lowish carb diet without needing keto, and I can eat some small amounts of carby treats without blowing the bank. My HbA1c over the last 4 years have all come in around 42 or 44 and LC is one lifestyle I can maintain without too much sweat or angst. Lastly, the hypos from Glic when they occur tend to be fairly mild and short lived providing you are producing your own internal insulin (you would not be on Glic if you weren't, anyway) Glic has a short half life of about an hour, then your liver should have compensated by upping the glucose again. But I find my 40mg tab can drop my bgl by about 4 mmol/l [/QUOTE]
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