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Diabetes Discussion
Type 1 Diabetes
Should Family Members Be "screened" For T1d Genes?
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<blockquote data-quote="Indy51" data-source="post: 1880231" data-attributes="member: 48386"><p>There is no single gene that specifies that someone will 100% get any autoimmune condition. It just doesn't work that way. It's a risk factor but not a guarantee.</p><p></p><p>Autoimmune disease = genetic predisposition + environmental trigger + intestinal permeability. If any one of these 3 factors is absent, no disease is triggered that is why onset can be separated by many years in any one individual.</p><p></p><p>Autoimmune disease is not the same as autosomal diseases like Huntington's.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874193/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874193/</a></p></blockquote><p></p>
[QUOTE="Indy51, post: 1880231, member: 48386"] There is no single gene that specifies that someone will 100% get any autoimmune condition. It just doesn't work that way. It's a risk factor but not a guarantee. Autoimmune disease = genetic predisposition + environmental trigger + intestinal permeability. If any one of these 3 factors is absent, no disease is triggered that is why onset can be separated by many years in any one individual. Autoimmune disease is not the same as autosomal diseases like Huntington's. [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874193/[/URL] [/QUOTE]
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Should Family Members Be "screened" For T1d Genes?
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