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Type 2 Diabetes
Slow acting insulin once a day
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<blockquote data-quote="EllieM" data-source="post: 2434157" data-attributes="member: 372717"><p>My understanding (possibly incorrect, this is a very complicated subject and the mechanisms appear to be disputed) is that long term high blood sugars damage beta cells, though this damage can be reversed to some extent by normalising blood sugars. (Unlike autoimmune beta cell destruction in T1s, where when they are gone they are gone.) So long term (eg ten years) T2s can end up with reduced insulin production, at which point insulin may be the best treatment for them. The articles I googled seemed to agree that beta cell decline was a given, though they argue about the mechanisms....</p><p></p><p>eg </p><p><a href="https://diabetes.diabetesjournals.org/content/54/suppl_2/S108" target="_blank">Mechanisms of β-Cell Death in Type 2 Diabetes | Diabetes (diabetesjournals.org)</a></p></blockquote><p></p>
[QUOTE="EllieM, post: 2434157, member: 372717"] My understanding (possibly incorrect, this is a very complicated subject and the mechanisms appear to be disputed) is that long term high blood sugars damage beta cells, though this damage can be reversed to some extent by normalising blood sugars. (Unlike autoimmune beta cell destruction in T1s, where when they are gone they are gone.) So long term (eg ten years) T2s can end up with reduced insulin production, at which point insulin may be the best treatment for them. The articles I googled seemed to agree that beta cell decline was a given, though they argue about the mechanisms.... eg [URL='https://diabetes.diabetesjournals.org/content/54/suppl_2/S108']Mechanisms of β-Cell Death in Type 2 Diabetes | Diabetes (diabetesjournals.org)[/URL] [/QUOTE]
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