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<blockquote data-quote="Adelle0607" data-source="post: 597074" data-attributes="member: 116645"><p>Film coating can also be applied to the desired function of the medication: immediate release, sustained release and enteric release.</p><p></p><p>I stand to be corrected, but best not to rely on memory alone (it's been years since my pharmacokinetics!) and back it up with articles. metformin xr is indeed sustained release formulation relying on the osmotic technology/ dual hydrophilic (water loving) polymer matrix system. The active core formulation/drug is surrounded by a semi permeable membrane that is permeable (can pass through) to water. Upon ingestion of the drug, water passes thru the membrane which then dissolves the drug and is released via exit ports in the membrane. Drug is released slowly via diffusion/osmotic gradient and this exists till there is undissolved drug left in the core tablet. Once all of it is dissolved, osmotic gradient then after awhile goes back to zero and delivery is finished.</p><p></p><p>Also for sustained release as well as enteric, it should be swallowed in whole and should not be crushed or chewed to get desired effect (sustained release or enteric effect)</p><p></p><p>Sources:</p><p></p><p><a href="http://www.drugs.com/pro/glucophage.html" target="_blank">http://www.drugs.com/pro/glucophage.html</a></p><p></p><p><a href="http://www.patient.co.uk/medicine/Metformin.htm" target="_blank">http://www.patient.co.uk/medicine/Metformin.htm</a></p><p> </p><p></p><p></p><p></p><p></p><p>Sent from the <a href="http://www.diabetes.co.uk/app/?utm_source=sig&utm_medium=txt&utm_campaign=appsig" target="_blank">Diabetes Forum App</a></p></blockquote><p></p>
[QUOTE="Adelle0607, post: 597074, member: 116645"] Film coating can also be applied to the desired function of the medication: immediate release, sustained release and enteric release. I stand to be corrected, but best not to rely on memory alone (it's been years since my pharmacokinetics!) and back it up with articles. metformin xr is indeed sustained release formulation relying on the osmotic technology/ dual hydrophilic (water loving) polymer matrix system. The active core formulation/drug is surrounded by a semi permeable membrane that is permeable (can pass through) to water. Upon ingestion of the drug, water passes thru the membrane which then dissolves the drug and is released via exit ports in the membrane. Drug is released slowly via diffusion/osmotic gradient and this exists till there is undissolved drug left in the core tablet. Once all of it is dissolved, osmotic gradient then after awhile goes back to zero and delivery is finished. Also for sustained release as well as enteric, it should be swallowed in whole and should not be crushed or chewed to get desired effect (sustained release or enteric effect) Sources: [url]http://www.drugs.com/pro/glucophage.html[/url] [url]http://www.patient.co.uk/medicine/Metformin.htm[/url] Sent from the [url=http://www.diabetes.co.uk/app/?utm_source=sig&utm_medium=txt&utm_campaign=appsig]Diabetes Forum App[/url] [/QUOTE]
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