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<blockquote data-quote="SimonCrox" data-source="post: 1802755" data-attributes="member: 388174"><p>Everyone is an individual, but the following study looked at what happenned to diabetic folk who achieved one, two or three goals (glucose, blood pressure, cholesterol (LDL cholesterol in this study). Patients who achieved LDL-C goals had decreased risk of complications and mortality compared with patients who achieved other goals but did not reach the LDL-C goal. I accept that it is observational rarher than a randomised prospective trial. STENO was a RCT and it showed that one had to strive to hit as many targets as possible, but cos of small sample size, was not possible to say which was the most improtant target. This is why the majority of doctors push the statins. I do accept that statin side effects are poorly appreciated by medical staff - trials showed statins well tolerated egHPS, but those that did not tolerate were excluded in the run in to the trial. Ezetimibe has been shown to be effective in diabetic folk in EVIDENT ( I think that is the correct name), and ezetimibe is very well tolerated but there are far more statin trials than ezetimibe trials.</p><p></p><p><a href="https://www.practiceupdate.com/journalscan/45458/3/8?elsca1=emc_enews_top-10&elsca2=email&elsca3=practiceupdate_diab&elsca4=diabetes&elsca5=newsletter&rid=MTAwOTY4MDQ3Nzg1S0&lid=10332481" target="_blank">https://www.practiceupdate.com/journalscan/45458/3/8?elsca1=emc_enews_top-10&elsca2=email&elsca3=practiceupdate_diab&elsca4=diabetes&elsca5=newsletter&rid=MTAwOTY4MDQ3Nzg1S0&lid=10332481</a></p><p></p><p>Fasting probably doesn't alter the cholesterol levels much, (not ure what I have done with the reference), and is a pain, but it is necessary if you want to look at the triglyceride levels, unfortunately. However, generallyy one is treating the cholesterol levels primarily.</p><p></p><p>I'm sorry - haven't had time to look at the video, and the most recent NICE guidance on statins just is too long.</p><p>Best wishes</p></blockquote><p></p>
[QUOTE="SimonCrox, post: 1802755, member: 388174"] Everyone is an individual, but the following study looked at what happenned to diabetic folk who achieved one, two or three goals (glucose, blood pressure, cholesterol (LDL cholesterol in this study). Patients who achieved LDL-C goals had decreased risk of complications and mortality compared with patients who achieved other goals but did not reach the LDL-C goal. I accept that it is observational rarher than a randomised prospective trial. STENO was a RCT and it showed that one had to strive to hit as many targets as possible, but cos of small sample size, was not possible to say which was the most improtant target. This is why the majority of doctors push the statins. I do accept that statin side effects are poorly appreciated by medical staff - trials showed statins well tolerated egHPS, but those that did not tolerate were excluded in the run in to the trial. Ezetimibe has been shown to be effective in diabetic folk in EVIDENT ( I think that is the correct name), and ezetimibe is very well tolerated but there are far more statin trials than ezetimibe trials. [URL]https://www.practiceupdate.com/journalscan/45458/3/8?elsca1=emc_enews_top-10&elsca2=email&elsca3=practiceupdate_diab&elsca4=diabetes&elsca5=newsletter&rid=MTAwOTY4MDQ3Nzg1S0&lid=10332481[/URL] Fasting probably doesn't alter the cholesterol levels much, (not ure what I have done with the reference), and is a pain, but it is necessary if you want to look at the triglyceride levels, unfortunately. However, generallyy one is treating the cholesterol levels primarily. I'm sorry - haven't had time to look at the video, and the most recent NICE guidance on statins just is too long. Best wishes [/QUOTE]
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