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<blockquote data-quote="Bubbleblower" data-source="post: 2395960" data-attributes="member: 540059"><p>Same here, I found my bloodsugar goes back up if I exercise any less. Here are two studies that specifically looked at the effect of not exercising (I can't link them yet).</p><p></p><p>"<a href="https://journals.physiology.org/doi/abs/10.1152/jappl.1983.55.2.512" target="_blank"><strong>Effects of exercise and lack of exercise on glucose tolerance and insulin sensitivity</strong></a>", which says:</p><p></p><p>"The blunted insulinresponse to a glucose load is lost rapidly, before significant changes in TO, max and body fat content occur, when physically trained individuals stop exercising. There is a concomitant decline in insulin binding to monocytes and a decrease in sensitivity to insulin, which was reflected in our subjects by higher glucose levels despite much higher plasma insulin concentrations following a glucose load"*.</p><p></p><p>And:</p><p></p><p>“<strong><a href="https://journals.physiology.org/doi/abs/10.1152/jappl.1988.64.5.1942" target="_blank">Effects of exercise and lack of exercise on insulin sensitivity and responsiveness</a>”</strong>, which says:</p><p></p><p>* "The plasma insulin response to an oral glucose load was more than twofold higher after 10 days without exercise than when the subjects were exercising regularly".</p><p></p><p></p><p></p><p>In many or may be all cases the control mechanisms aren't working properly. You'll find this study interesting:</p><p></p><p>"<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373662/" target="_blank"><strong>Role of transcription factors in the transdifferentiation of pancreatic islet cells</strong></a>":</p><p></p><p>“β-to-α as well as α-to-β transdifferentiation can take place under certain experimental circumstances”.</p><p></p><p>“While diabetes is traditionally cast as a disease of relative (type 2) or absolute (type 1) insufficiency in β cell mass, it is less appreciated that hyperglucagonemia secondary to the loss of the normal inhibitory tone on α cells from β cells contributes to the etiology of diabetes by aggravating hyperglycemia“.</p><p></p><p>This one is less interesting:</p><p></p><p>"<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689286/" target="_blank"><strong>Iterations in Beta Cell Identity in Type 1 and Type 2 Diabetes</strong></a>", but it says:</p><p></p><p>“altered identity of mature β cells in diabetes also involves transdifferentiation of β cells into other islet hormone producing cells. For example, overexpression of α cell specific transcription factor Arx or ablation of Pdx1 resulted in an increase of α cell numbers and a decrease in β cell numbers in rodents”.</p><p></p><p>I have a ton of research on both these topics, but unfortunately not that well organised, so it could take me forever to find a specific study.</p><p></p><p></p><p></p><p>I still have one question if you dont mind; how do you (or does one) know you have LADA?</p><p></p><p></p><p>Edited to fix the layout and to insert the links.</p></blockquote><p></p>
[QUOTE="Bubbleblower, post: 2395960, member: 540059"] Same here, I found my bloodsugar goes back up if I exercise any less. Here are two studies that specifically looked at the effect of not exercising (I can't link them yet). "[URL='https://journals.physiology.org/doi/abs/10.1152/jappl.1983.55.2.512'][B]Effects of exercise and lack of exercise on glucose tolerance and insulin sensitivity[/B][/URL]", which says: "The blunted insulinresponse to a glucose load is lost rapidly, before significant changes in TO, max and body fat content occur, when physically trained individuals stop exercising. There is a concomitant decline in insulin binding to monocytes and a decrease in sensitivity to insulin, which was reflected in our subjects by higher glucose levels despite much higher plasma insulin concentrations following a glucose load"*. And: “[B][URL='https://journals.physiology.org/doi/abs/10.1152/jappl.1988.64.5.1942']Effects of exercise and lack of exercise on insulin sensitivity and responsiveness[/URL]”[/B], which says: * "The plasma insulin response to an oral glucose load was more than twofold higher after 10 days without exercise than when the subjects were exercising regularly". In many or may be all cases the control mechanisms aren't working properly. You'll find this study interesting: "[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373662/'][B]Role of transcription factors in the transdifferentiation of pancreatic islet cells[/B][/URL]": “β-to-α as well as α-to-β transdifferentiation can take place under certain experimental circumstances”. “While diabetes is traditionally cast as a disease of relative (type 2) or absolute (type 1) insufficiency in β cell mass, it is less appreciated that hyperglucagonemia secondary to the loss of the normal inhibitory tone on α cells from β cells contributes to the etiology of diabetes by aggravating hyperglycemia“. This one is less interesting: "[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689286/'][B]Iterations in Beta Cell Identity in Type 1 and Type 2 Diabetes[/B][/URL]", but it says: “altered identity of mature β cells in diabetes also involves transdifferentiation of β cells into other islet hormone producing cells. For example, overexpression of α cell specific transcription factor Arx or ablation of Pdx1 resulted in an increase of α cell numbers and a decrease in β cell numbers in rodents”. I have a ton of research on both these topics, but unfortunately not that well organised, so it could take me forever to find a specific study. I still have one question if you dont mind; how do you (or does one) know you have LADA? Edited to fix the layout and to insert the links. [/QUOTE]
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