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'Switch' in brain linked to weight gain.
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<blockquote data-quote="Kansenji" data-source="post: 27194" data-attributes="member: 9050"><p>DAILY TELEGRAPH ARTICLE: (bold highlights added by me)</p><p></p><p>Scientists think they have found a "switch" in the brain that is linked to weight gain.</p><p>If it is faulty then rather than recognising that the body is full, the brain sends out signals to eat more and to store more sugars as fat.</p><p></p><p>The mechanism also has a direct link to obesity-linked disorders such as <strong>type 2 diabetes</strong> and heart disease, scientists believe. A study suggests that drugs could be used to suppress this switch and help people get back to a healthy weight.</p><p></p><p>Scientists working with mice made the discovery in the hypothalamus, a part of the brain that links the nervous system to the hormones affecting metabolic processes. </p><p>Among other things, the hypothalamus helps to regulate <strong>body temperature, hunger and thirst. </strong></p><p></p><p>The switch, a protein complex called NF-kappaB, is primarily associated with the immune system. Scientists say that in the past it used to help the body fight infection, but it now influences food intake and metabolism. One of its effects is to create <strong>resistance to insulin</strong> and resistance to the "feeling full" hormone leptin, which controls appetite. This can lead to more food being eaten and the generation of obesity.</p><p></p><p>LINK: <a href="http://www.telegraph.co.uk/news/newstopics/politics/health/3126710/Switch-in-brain-linked-to-weight-gain.html" target="_blank">http://www.telegraph.co.uk/news/newstopics/politics/health/3126710/Switch-in-brain-linked-to-weight-gain.html</a></p></blockquote><p></p>
[QUOTE="Kansenji, post: 27194, member: 9050"] DAILY TELEGRAPH ARTICLE: (bold highlights added by me) Scientists think they have found a "switch" in the brain that is linked to weight gain. If it is faulty then rather than recognising that the body is full, the brain sends out signals to eat more and to store more sugars as fat. The mechanism also has a direct link to obesity-linked disorders such as [b]type 2 diabetes[/b] and heart disease, scientists believe. A study suggests that drugs could be used to suppress this switch and help people get back to a healthy weight. Scientists working with mice made the discovery in the hypothalamus, a part of the brain that links the nervous system to the hormones affecting metabolic processes. Among other things, the hypothalamus helps to regulate [b]body temperature, hunger and thirst. [/b] The switch, a protein complex called NF-kappaB, is primarily associated with the immune system. Scientists say that in the past it used to help the body fight infection, but it now influences food intake and metabolism. One of its effects is to create [b]resistance to insulin[/b] and resistance to the "feeling full" hormone leptin, which controls appetite. This can lead to more food being eaten and the generation of obesity. LINK: [url]http://www.telegraph.co.uk/news/newstopics/politics/health/3126710/Switch-in-brain-linked-to-weight-gain.html[/url] [/QUOTE]
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