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Testing insulin activity length
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<blockquote data-quote="tim2000s" data-source="post: 1946713" data-attributes="member: 30007"><p>This is always an interesting point. Put simply, most observational attempts to determine how long insulin lasts in the body come up with an answer that is way too short, for a number of reasons. I've written about it <a href="https://www.diabettech.com/insulin/why-we-are-regularly-wrong-in-the-duration-of-insulin-action-dia-times-we-use-and-why-it-matters/" target="_blank">here</a> but it comes down to clearance time, and the studies that have been done on insulin clearance all show that subcutaneous insulin has a half life of roughly 55 minutes. This appears to be reasonably consistent across adults and children and doesn't seem to vary very much. So the story that we get from HCPs about insulin lasting 3 to 5 hours is generally wrong.</p><p></p><p>The observable effects often stop showing up after around 3-5 hours (dependent on dose) simply because of the way decay works, but for the vast majority of people, there is still insulin on board at 5+ hours, and this really becomes noticeable when we exercise.</p><p></p><p>The other aspect of this is that because we have been told that insulin lasts three hours, we tend to set up our basal dosing with this expectation in mind and also observe with this in mind, so the overall effect is that when we try and observe duration, we aren't starting from a technically correct place.</p></blockquote><p></p>
[QUOTE="tim2000s, post: 1946713, member: 30007"] This is always an interesting point. Put simply, most observational attempts to determine how long insulin lasts in the body come up with an answer that is way too short, for a number of reasons. I've written about it [URL='https://www.diabettech.com/insulin/why-we-are-regularly-wrong-in-the-duration-of-insulin-action-dia-times-we-use-and-why-it-matters/']here[/URL] but it comes down to clearance time, and the studies that have been done on insulin clearance all show that subcutaneous insulin has a half life of roughly 55 minutes. This appears to be reasonably consistent across adults and children and doesn't seem to vary very much. So the story that we get from HCPs about insulin lasting 3 to 5 hours is generally wrong. The observable effects often stop showing up after around 3-5 hours (dependent on dose) simply because of the way decay works, but for the vast majority of people, there is still insulin on board at 5+ hours, and this really becomes noticeable when we exercise. The other aspect of this is that because we have been told that insulin lasts three hours, we tend to set up our basal dosing with this expectation in mind and also observe with this in mind, so the overall effect is that when we try and observe duration, we aren't starting from a technically correct place. [/QUOTE]
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