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<blockquote data-quote="cugila" data-source="post: 93189" data-attributes="member: 15325"><p>LEPTIN. I understood it had more of a connection with Obesity ? Is there more specific research/trials relating to Diabetes.</p><p></p><p>An extract:</p><p>Pharmacological use of leptin</p><p>Unsurprisingly there was huge media interest in leptin as it was thought of as the miracle cure for obesity and the biotechnology company Amgen paid $20 million to license leptin. However the results of the clinical trials on obese people were disappointing with very few of the participants losing weight. It appeared that the majority of people were not obese due to a deficiency in leptin but were just unable to respond to it; they had more fat cells and so more circulating leptin and as a result reduced sensitivity of the leptin receptor. The failure of the trial, however, overshadowed the fact that around 30% of the people did actually lose weight and so may actually have low circulating levels of leptin. Potentially these people would then indeed benefit from leptin therapy. The task now though is to determine those people that have a lower circulating level of leptin, a mammoth task.</p><p></p><p>The use of leptin as a drug has proved invaluable in the disease lipodystrophy and in people who have a defective leptin gene and so are constantly hungry. Administration of leptin has provided a cure for these diseases.</p><p></p><p>Here is a link to the full article:</p><p><a href="http://www.eurodiabesity.org/Leptin.htm" target="_blank">http://www.eurodiabesity.org/Leptin.htm</a></p></blockquote><p></p>
[QUOTE="cugila, post: 93189, member: 15325"] LEPTIN. I understood it had more of a connection with Obesity ? Is there more specific research/trials relating to Diabetes. An extract: Pharmacological use of leptin Unsurprisingly there was huge media interest in leptin as it was thought of as the miracle cure for obesity and the biotechnology company Amgen paid $20 million to license leptin. However the results of the clinical trials on obese people were disappointing with very few of the participants losing weight. It appeared that the majority of people were not obese due to a deficiency in leptin but were just unable to respond to it; they had more fat cells and so more circulating leptin and as a result reduced sensitivity of the leptin receptor. The failure of the trial, however, overshadowed the fact that around 30% of the people did actually lose weight and so may actually have low circulating levels of leptin. Potentially these people would then indeed benefit from leptin therapy. The task now though is to determine those people that have a lower circulating level of leptin, a mammoth task. The use of leptin as a drug has proved invaluable in the disease lipodystrophy and in people who have a defective leptin gene and so are constantly hungry. Administration of leptin has provided a cure for these diseases. Here is a link to the full article: [url=http://www.eurodiabesity.org/Leptin.htm]http://www.eurodiabesity.org/Leptin.htm[/url] [/QUOTE]
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