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Thiamine deficiency in diabetics
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<blockquote data-quote="Bombjack" data-source="post: 1735221" data-attributes="member: 470766"><p>What we can say, is to keep blood glucose as low as practicable. Everyone agrees on that I think, and it has to be a diabetic's highest priority.</p><p></p><p>Beyond that, it's not clear at all. The 4 pathways for diabetic complications were idenitified by the early 90's, and there is broad agreement that they make sense. But how to affect these pathways, to minimise damage? One thing's for sure. It won't be done with just one wonder-drug. There are too many pathways, too many moving parts, involved.</p><p></p><p>Thiamine is a no-brainer for me, because it's cheap, and has no side-effects (except colouring your wee bright yellow) <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /></p><p></p><p>If I had to suggest other items for a "Master List", I would go for:</p><p></p><p><strong>Glycine & Cystine </strong>- for Glutathione synthesis - Aldose Reductase Inhibitor & master antioxidant. Found to be deficient due to increased use, in Diabetics.</p><p><strong>Alpha-Lipoic Acid</strong> - Recycling of Glutathione within cells,</p><p><strong>Vitamin C</strong> - Aldose Reductase inhibitor, and general anti-oxidant.</p><p><strong>Metformin </strong>- Glyoxalase promoter</p><p><strong>Leutine </strong>- Deficient in diabetics. Used in the retina, and I noticed an improvement in my vision after taking it, so I'm putting it here! </p><p></p><p>And there are many, many more to choose from. Scientific studies are out there, but they haven't been carried through to practise for a variety of reasons. Still, taking a few supplements at least makes me feel like I'm doing something positive <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /></p></blockquote><p></p>
[QUOTE="Bombjack, post: 1735221, member: 470766"] What we can say, is to keep blood glucose as low as practicable. Everyone agrees on that I think, and it has to be a diabetic's highest priority. Beyond that, it's not clear at all. The 4 pathways for diabetic complications were idenitified by the early 90's, and there is broad agreement that they make sense. But how to affect these pathways, to minimise damage? One thing's for sure. It won't be done with just one wonder-drug. There are too many pathways, too many moving parts, involved. Thiamine is a no-brainer for me, because it's cheap, and has no side-effects (except colouring your wee bright yellow) :) If I had to suggest other items for a "Master List", I would go for: [B]Glycine & Cystine [/B]- for Glutathione synthesis - Aldose Reductase Inhibitor & master antioxidant. Found to be deficient due to increased use, in Diabetics. [B]Alpha-Lipoic Acid[/B] - Recycling of Glutathione within cells, [B]Vitamin C[/B] - Aldose Reductase inhibitor, and general anti-oxidant. [B]Metformin [/B]- Glyoxalase promoter [B]Leutine [/B]- Deficient in diabetics. Used in the retina, and I noticed an improvement in my vision after taking it, so I'm putting it here! And there are many, many more to choose from. Scientific studies are out there, but they haven't been carried through to practise for a variety of reasons. Still, taking a few supplements at least makes me feel like I'm doing something positive :) [/QUOTE]
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