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Message: <blockquote data-quote="LittleGreyCat" data-source="post: 1623237" data-attributes="member: 6467">The algebra left me confused, but I think it is more or less saying:If you are on Metformin then high average HbA1c can reduce your life expectancy. I assume that they assume that you will rarely if ever be skirting hypo territory. There must be other drugs which lower BG without a hypo risk as well.If you are on insulin and/or other drugs which actively lower BG and therefore carry the constant risk of hypos, then maintaining a low average HbA1c can increase your risk of mortality.There is no explanation of the causes. It may well be that to maintain a low average HbA1c you have to constantly skirt hypo territory and that this is more damaging than running a higher (but not very high) average HbA1c. This could be very important for out T1 friends because there is the temptation to try and maintain "normal" levels of BG with strict control. I am sure i have read debates where HCPs and T1s have disagreed about targets.One confusing thing is that it seems to imply that if you are on insulin et. al. then running high HbA1c averages doesn't reduce your life expectancy but if you are just on Metformin then it does.More research (or at least more detail) needed.</blockquote>

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