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<blockquote data-quote="Indy51" data-source="post: 2225545" data-attributes="member: 48386"><p>I've come to the conclusion that I might fit into the insulin deficient category, though of course it's hard to be sure. I do have a genetic SNP (apparently a quite common one) that decreases first phase insulin by 19% as follows:</p><p></p><p><em><strong>rs13266634(C;C) </strong>- increased risk for type-2 diabetes - rs13266634 is a SNP in the zinc transporter protein member 8 SLC30A8 gene that has primarily been associated with type-2 diabetes in several studies. This SNP is also known as the Arg325Trp or R325W variant; the (C) allele encodes the arginine (R), and the (T) allele encodes the tryptophan (W). significantly associated p = 0.0073; in 1,630 Japanese subjects with type-2 diabetes and in 1,064 controls. The major alleles of the SLC30A8 SNP rs13266634 and the HHEX SNP rs7923837 associate with <strong>reduced insulin secretion, but not with insulin resistance</strong>. 46% of European non-diabetic offspring of type-2 diabetes patients are rs13266634<strong>(C;C) homozygotes; they are diabetes-prone and characterised by a 19% decrease in first-phase insulin release following an intravenous glucose load.</strong></em></p><p><em><strong></strong></em></p><p>It might explain my situation and why I still have post-prandial highs if I go above around 30g carbs in any one meal. I still get normal A1c readings and have done so since losing weight after initial diagnosis. I had a history of getting a pre-diabetic diagnosis every time I quit smoking and put on around 20kgs - happened 3 times in all until finally getting diagnosed as Type 2. I also have an ultrasound showing fatty liver and pancreas about the same time.</p><p></p><p>I've had scans since losing the excess weight that show no evidence of fatty liver or pancreas, yet I still don't manage normal post-prandial responses to carbs, even if I'm eating higher carbs for several weeks. I'm about a week away from my 8 year diaversary and presumably all/most of the cells in my body have turned over since diagnosis, yet nothing's really changed. It's one of the many reasons I don't consider myself reversed, in remission or any of those other descriptors. I'm currently at my lightest weight since diagnosis and eating more carbs, but would never feel comfortable going back to the levels of carbs I used to eat pre-diagnosis. I don't plan to ever call myself anything other than 'well controlled by diet'.</p></blockquote><p></p>
[QUOTE="Indy51, post: 2225545, member: 48386"] I've come to the conclusion that I might fit into the insulin deficient category, though of course it's hard to be sure. I do have a genetic SNP (apparently a quite common one) that decreases first phase insulin by 19% as follows: [I][B]rs13266634(C;C) [/B]- increased risk for type-2 diabetes - rs13266634 is a SNP in the zinc transporter protein member 8 SLC30A8 gene that has primarily been associated with type-2 diabetes in several studies. This SNP is also known as the Arg325Trp or R325W variant; the (C) allele encodes the arginine (R), and the (T) allele encodes the tryptophan (W). significantly associated p = 0.0073; in 1,630 Japanese subjects with type-2 diabetes and in 1,064 controls. The major alleles of the SLC30A8 SNP rs13266634 and the HHEX SNP rs7923837 associate with [B]reduced insulin secretion, but not with insulin resistance[/B]. 46% of European non-diabetic offspring of type-2 diabetes patients are rs13266634[B](C;C) homozygotes; they are diabetes-prone and characterised by a 19% decrease in first-phase insulin release following an intravenous glucose load. [/B][/I] It might explain my situation and why I still have post-prandial highs if I go above around 30g carbs in any one meal. I still get normal A1c readings and have done so since losing weight after initial diagnosis. I had a history of getting a pre-diabetic diagnosis every time I quit smoking and put on around 20kgs - happened 3 times in all until finally getting diagnosed as Type 2. I also have an ultrasound showing fatty liver and pancreas about the same time. I've had scans since losing the excess weight that show no evidence of fatty liver or pancreas, yet I still don't manage normal post-prandial responses to carbs, even if I'm eating higher carbs for several weeks. I'm about a week away from my 8 year diaversary and presumably all/most of the cells in my body have turned over since diagnosis, yet nothing's really changed. It's one of the many reasons I don't consider myself reversed, in remission or any of those other descriptors. I'm currently at my lightest weight since diagnosis and eating more carbs, but would never feel comfortable going back to the levels of carbs I used to eat pre-diagnosis. I don't plan to ever call myself anything other than 'well controlled by diet'. [/QUOTE]
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