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Message: <blockquote data-quote="Wannabeflatliner" data-source="post: 2700683" data-attributes="member: 468196">Hello,Bumping this thread as I am researching lately effect of metacresol and phenol in insulin on our body.Here are the different metacresol concentration depending on the insulin you use :<table style='width: 100%'><tr><td>NovoRapid and Fiasp</td><td>1.72 mg/ml</td></tr><tr><td>Humalog and Lyumjev</td><td>3.15 mg/ml</td></tr><tr><td>Apidra: Approximately </td><td>2.8 mg/ml</td></tr></table>Now I react to the insulin preparation of humalog (local skin redness/itchiness/inflammation) because of the higher concentration of metacresol but I do not react to novorapid or Fiasp.I have looked at other solutions to keep using Humalog and Luymjev (Luymjev being the fastest insulin on the market at the moment). They both come in U100 and U200 concentration. Both of them have the same concentration of metacresol. I was thinking if we use U200 formulation, and mix 50% normal salin and 50% U200, we could have the equivalent of U100 insulin but with half the concentration of metacresol!! I dont know if this has been tried already.I did find an article where they mixed insulin with normal salin in an insulin pump for a child with minimal insulin need, so mixing with normal salin seems to be feasable (Article named : Use of Lispro Insulin Diluted with Normal Saline to 10 U/ml in an Insulin Pump: Case Report) ... I don't know if anybody has experience with that?</blockquote>

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