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Toxicity of insulin due to phenol and metacresol
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<blockquote data-quote="Nnora" data-source="post: 1080914" data-attributes="member: 258798"><p>Hi everyone,</p><p> I was wondering if anyone here was thinking about toxic substances present in insulin formulations. For example, Novorapid contains 1.5 mg/ml of phenol and 1.72 mg/ml of metacresol. Both of these substances are very toxic, and for someone who is injecting 20 units of insulin per day, means also 300 ppm of phenol per day and 344 ppm of m-cresol. </p><p>Here is the study that was dealing with cell death induced with these substances.</p><p><a href="http://www.sciencedirect.com/science/article/pii/S2214750014001541" target="_blank">http://www.sciencedirect.com/science/article/pii/S2214750014001541</a></p><p>On the other hand, I understand that for the purification step, in the production of insulin, phenol is used to separate protein from DNA, but there must be an alternative which is safer.</p></blockquote><p></p>
[QUOTE="Nnora, post: 1080914, member: 258798"] Hi everyone, I was wondering if anyone here was thinking about toxic substances present in insulin formulations. For example, Novorapid contains 1.5 mg/ml of phenol and 1.72 mg/ml of metacresol. Both of these substances are very toxic, and for someone who is injecting 20 units of insulin per day, means also 300 ppm of phenol per day and 344 ppm of m-cresol. Here is the study that was dealing with cell death induced with these substances. [URL]http://www.sciencedirect.com/science/article/pii/S2214750014001541[/URL] On the other hand, I understand that for the purification step, in the production of insulin, phenol is used to separate protein from DNA, but there must be an alternative which is safer. [/QUOTE]
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Toxicity of insulin due to phenol and metacresol
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