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Type 1 Diabetes
Toxicity of insulin due to phenol and metacresol
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<blockquote data-quote="Dark Horse" data-source="post: 1081256" data-attributes="member: 52527"><p>Not sure why you are quoting ppm (parts per million)? If Novorapid has 100 units per ml then 20 units will be contained in 0.2 mls. At the concentrations quoted, this volume will contain a total of 0.3 mg (300 micrograms) of phenol and 0.344mg (344 micrograms) of metacresol.</p><p></p><p>Insulin would be dangerous if contaminated with pathogens so it is better to have permitted levels of preservatives and follow the advice of the article quoted, "To minimize acute skin complications caused by phenol/<em>m</em>-cresol accumulation, a frequent change of infusion sets and rotation of the infusion site is recommended."</p></blockquote><p></p>
[QUOTE="Dark Horse, post: 1081256, member: 52527"] Not sure why you are quoting ppm (parts per million)? If Novorapid has 100 units per ml then 20 units will be contained in 0.2 mls. At the concentrations quoted, this volume will contain a total of 0.3 mg (300 micrograms) of phenol and 0.344mg (344 micrograms) of metacresol. Insulin would be dangerous if contaminated with pathogens so it is better to have permitted levels of preservatives and follow the advice of the article quoted, "To minimize acute skin complications caused by phenol/[I]m[/I]-cresol accumulation, a frequent change of infusion sets and rotation of the infusion site is recommended." [/QUOTE]
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Toxicity of insulin due to phenol and metacresol
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