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Type 1 Diabetes
Toxicity of insulin due to phenol and metacresol
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<blockquote data-quote="tim2000s" data-source="post: 1081783" data-attributes="member: 30007"><p>[USER=140811]@urbanracer[/USER] The details of Insulin Aspart state 1.5mg/ml, as mentioned in the FDA briefing on the product. <a href="http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4254b_13_04_KP%20InsulinAspartFDAlabel102005.pdf" target="_blank">http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4254b_13_04_KP InsulinAspartFDAlabel102005.pdf</a></p><p></p><p>However, I personally inject <50u of Novorapid daily, so I'd be experiencing the effect of <0.75mg of phenol, which is well under what are considered to be "safe" levels. </p><p></p><p>On that point, it's also worth noting that in the statement in the science direct paper, phenol was noted to cause cellular death when the levels exceeded 1.2mg/ml/24 hours. </p><p></p><p>It's also worth noting that the levels at which adipocytes were damaged (with Phenol) was at 2.3mg/ml/24 hours and upwards. Again, this is a high amount of insulin.</p><p></p><p>In other words, what I take away from the study is that larger amounts of insulin, which increase the phenol and m-cresol concentration in cells, cause greater cell damage. That ignores that high levels of exogenous insulin also cause other metabolic issues that probably far outweigh the cell damage concerns. </p><p></p><p>The key point of the study appears to be to identify whether it is the Phenol/m-Cresol components of insulin as well as the invasive nature of the cannula that results in tissue damage, or whether it is just the latter. As the study says, more investigation is needed from both a control and testing inhibitors that may make a difference perspective.</p><p></p><p>As a footnote, I note that even when not continually infusing insulin through an injection port, there is still a similar level of irritation, so I question whether the hypothesis that it is heavily attributable to stability enhancers in the insulin is accurate. </p><p></p><p>In the meantime, I intend to continue to take insulin and stay alive.</p></blockquote><p></p>
[QUOTE="tim2000s, post: 1081783, member: 30007"] [USER=140811]@urbanracer[/USER] The details of Insulin Aspart state 1.5mg/ml, as mentioned in the FDA briefing on the product. [URL]http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4254b_13_04_KP%20InsulinAspartFDAlabel102005.pdf[/URL] However, I personally inject <50u of Novorapid daily, so I'd be experiencing the effect of <0.75mg of phenol, which is well under what are considered to be "safe" levels. On that point, it's also worth noting that in the statement in the science direct paper, phenol was noted to cause cellular death when the levels exceeded 1.2mg/ml/24 hours. It's also worth noting that the levels at which adipocytes were damaged (with Phenol) was at 2.3mg/ml/24 hours and upwards. Again, this is a high amount of insulin. In other words, what I take away from the study is that larger amounts of insulin, which increase the phenol and m-cresol concentration in cells, cause greater cell damage. That ignores that high levels of exogenous insulin also cause other metabolic issues that probably far outweigh the cell damage concerns. The key point of the study appears to be to identify whether it is the Phenol/m-Cresol components of insulin as well as the invasive nature of the cannula that results in tissue damage, or whether it is just the latter. As the study says, more investigation is needed from both a control and testing inhibitors that may make a difference perspective. As a footnote, I note that even when not continually infusing insulin through an injection port, there is still a similar level of irritation, so I question whether the hypothesis that it is heavily attributable to stability enhancers in the insulin is accurate. In the meantime, I intend to continue to take insulin and stay alive. [/QUOTE]
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Toxicity of insulin due to phenol and metacresol
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