Alineden
Well-Known Member
- Messages
- 136
- Location
- West Cumbria
- Type of diabetes
- Type 2
- Treatment type
- Tablets (oral)
- Dislikes
- Not much really
Where is all this glucose stored, bearing in mind that not all diabetics are overweight?Your body is crammed full of glucose through years of overexposure.
Where is all this glucose stored, bearing in mind that not all diabetics are overweight?
Glucose is stored in the liver and muscles as glycogen. In a "normal" person enough glycogen in the liver (about 100g) to keep their vital organs supplied for about a day without any input from food. The glycogen in the muscles (about 400g) is a rapid source of energy during exercise and lasts of the order of 90 minutes of continuous energy expenditure such as when distance running. So a "normal" person might completely deplete their stored glucose with a day of fasting and a 90 minute run and then have to rely on stored fat for energy. My concern is with your assertion that the tissues of a diabetic are chock-a-block with a decade’s worth of glucose that needs to be purged. How much glycogen do you think is stored in the liver and muscles of a diabetic and if not there, where else and in what form?According to Jason Fung, once fat cells and the the liver’s glcogen stores are full, the excess glucose accumulates in the blood, tissues and organs. Apparently it’s the reason why hypoglycaemics, and exogenous insulin especially, don’t tend to improve long term health outcomes in type 2s - because they just move the glucose out of the blood and into tissues, where it remains toxic and eventually causes complications, even if the blood appears clean. It’s this glucose that must be purged.
On the wider topic of T2DM and obesity - Stored body fat is glucose that’s been safely stored away, but we only have a finite amount of fat cells, and once they’re full, the glucose begins to accumulate in the blood and body. In fact, contrary to accepted dogma, obesity is actually a protective mechanism that delays the onset of diabetes. Some people, myself included, do not have many fat cells and thus are not able to become obese. In these people, the onset of type 2 diabetes occurs much sooner than it would have if de novo lipogenesis had been able to safely convert more glucose into fat. I was 61kg when diagnosed type 2, so I’m no stranger to this theory
Glucose is stored in the liver and muscles as glycogen. In a "normal" person enough glycogen in the liver (about 100g) to keep their vital organs supplied for about a day without any input from food. The glycogen in the muscles (about 400g) is a rapid source of energy during exercise and lasts of the order of 90 minutes of continuous energy expenditure such as when distance running. So a "normal" person might completely deplete their stored glucose with a day of fasting and a 90 minute run and then have to rely on stored fat for energy. My concern is with your assertion that the tissues of a diabetic are chock-a-block with a decade’s worth of glucose that needs to be purged. How much glycogen do you think is stored in the liver and muscles of a diabetic and if not there, where else and in what form?
Maybe you could save me from having to read the whole thing and just give me a quote where he explains how glucose is forced into tissues?It’s not my assertion, it’s the view of Jason Fung, and I’m fairly sure he knows more than both of us
We’re talking about glucose being forced into the tissues because the blood and glycogen stores are full, and the body is running out of places to store fat, not glycogen stores in the muscles and liver. He may be wrong but you’d have to take it up with him. From everything I’ve learned and experienced myself, though, he’s correct. It certainly explains why it takes several months to reverse diabetes, not one day and a jog around the block.
For more information read The Diabetes Code. Whilst it may not all be inscrutable fact, it’s very interesting and seems grounded in science and logic. Jason Fung is a word leader in reversing diabetes, and definitely isn’t a quack
Maybe you could save me from having to read the whole thing and just give me a quote where he explains how glucose is forced into tissues?
Sorry, I appreciate it can be difficult testing around work breaks but I don't think you can make a judgement about what is high at 40 mins when you did not test before the meal.Doesn't that seem high for what I've eaten?
Maybe you could save me from having to read the whole thing and just give me a quote where he explains how glucose is forced into tissues?
Insulin has several roles. One is to allow glucose into cells. Another is to stop glucose production and fat burning in the liver (gluconeogenesis). After this stops, then it stores glycogen in the liver and turns excessive carbohydrates and protein into fat via de novo lipogenesis. Insulin is basically a hormone to signal the body to store some of the incoming food energy, either as glycogen or fat.
Thanks for that PonchoThere are soooo many variables.
Something to consider. You know yourself best, so disregard if it will set you back.
Keep record of morning fasting level anyway.
I am like you w morning spike; especially if insomnia hits.
Here’s the exciting part:
This is a marathon of life.
My morning BG has improved over 6 months time.
I wouldn’t have seen this if I avoided the tracking due to discouragement.
Yet, I try not to weigh myself daily as fluctuations discourage!
Knowing yourself is vital.
I read advice from 1650 (seriously) that basically describes diabetes and low carb (honey) diet and intermittent fasting as remedy.
He (not a doctor) wrote that each person must reason within themself as we are all different.
He said combine observations of nature and our own appetites with our elevated reason.
Great stuff.
Thanks Squire FulwoodI was going to write something about GI and also protein spikes and the different shapes of spikes but I gave up. So here is a link to a thread elsewhere.
https://www.diabetes.co.uk/forum/threads/protein-and-delayed-bg-spikes.158681/
Thanks Jim. Another great reply. Plus you might have hit on something I hadn't mentioned. Last Friday was our anniversary and we went out for a meal. This wasn't the first meal out I've had since diagnosis but it was the first where I allowed myself free choice from the menu. When I got home my BG was 18mmol/l. I tested an hour later to see if it had gone up any more but it had dropped to 11 mmol/l.Keep in mind that meal-to-meal is not the whole picture. Your body is crammed full of glucose through years of overexposure. Your diabetes isn’t just a moment-to-moment reaction of the last thing you ate. It’s a combination of many factors, including but not limited to, your last meal and your current level of insulin resistance. The path to recovery isn’t just about making it from one meal to the next, it’s about purging your body of all that glucose that’s already there. This can take a very long time to achieve, depending on the progression of your condition and your commitment to fixing it. Sometimes you’ll find your blood glucose reactions are quite elastic, and very often dietary choices can have an effect days down the line.
Minimise insulin secretion at all times by limiting or eliminating carbohydrate. Keep moving as much as possible. In time, stability will return as your insulin sensitivity improves and your tissues aren’t chock-a-block with a decade’s worth of glucose. Small moves
Hi Mr_pot. In fairness I probably need to lose another 21 - 28lbWhere is all this glucose stored, bearing in mind that not all diabetics are overweight?
There a two things springing to mind here Jim. Firstly despite usually eating LCHF quite strictly my weight loss has been satisfactory but I've never seen even a trace of ketones when using a pee stick. Perhaps my body still has access to too much glucose regardless of what I eat.According to Jason Fung, once fat cells and the the liver’s glcogen stores are full, the excess glucose accumulates in the blood, tissues and organs. Apparently it’s the reason why hypoglycaemics, and exogenous insulin especially, don’t tend to improve long term health outcomes in type 2s - because they just move the glucose out of the blood and into tissues, where it remains toxic and eventually causes complications, even if the blood appears clean. It’s this glucose that must be purged.
On the wider topic of T2DM and obesity - Stored body fat is glucose that’s been safely stored away, but we only have a finite amount of fat cells, and once they’re full, the glucose begins to accumulate in the blood and body. In fact, contrary to accepted dogma, obesity is actually a protective mechanism that delays the onset of diabetes. Some people, myself included, do not have many fat cells and thus are not able to become obese. In these people, the onset of type 2 diabetes occurs much sooner than it would have if de novo lipogenesis had been able to safely convert more glucose into fat. I was 61kg when diagnosed type 2, so I’m no stranger to this theory
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