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Type 1.5 / Monogenic Diabetes

S

Sosban13

Newbie
Messages
1
Type of diabetes
Don't have diabetes
Treatment type
Insulin
Good Afternoon.
My Brother has recently been diagnosed with Type 1.5 or Monogenic Diabetes, something which I had never heard of before. He stated that it's due to a rogue chromosome or something like that. There is a long family history of it on one side.
Since his diagnosis, I have had a blood test and my levels were ok.

I worry for my brother as he's lost over 3 stone in weight, gone from a solid 15.5 stone to about 12.5ish and he's currently suffering a lot with his legs and feet. He complains about the stiffness and burning sensations in his feet. He's trying all sorts of techniques, to try and ease it.

As he's newly been diagnosed, does the burning and stiffness go in time and will he put weight back on for him to live a normal life?
All I can think and worry about is hearing stories about people having their legs amputated from diabetes.

thanks
 
Hi and welcome to the forum @Sosban13 . Sorry to hear about your brother. We have many members who are late onset Type 1 diabetes, who will be able to enlighten you through their own experiences.

Type 1.5 officially known as Late Onset Diabetes in Adults or (LADA) . Is sometimes called Type 1.5 due to similarities to Type 2 diabetes, but it is a sub group of Type 1 diabetes. My own brother has LADA. I am also in the at risk group due to my own genetics and a close family member with T1.
I have not heard of Monogenic Type 1 diabetes. Monogenic is usually known as MODY or Maturity-onset diabetes of the young. A confusing title as it can manifest in much older adults as well.

The two forms of diabetes have different causes. LADA (1.5) is an autoimmune form of diabetes and MODY (Monogenic diabetes) is caused by a mutation in a single gene. It is not autoimmune, but happy to stand corrected if there is a rare variant.

LADA also has a genetic cause, but a wider number of genes are involved. If you don’t have the susceptible genes then you will not develop LADA (TI/1.5) .

I’ll dig out some sources for my post.
ed spelling

Edited to add sources.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5491594/

https://www.ncbi.nlm.nih.gov/books/NBK532900/
 
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