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Type 1 Diabetes
Type 1's - I need your thoughts!
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<blockquote data-quote="tim2000s" data-source="post: 1105762" data-attributes="member: 30007"><p>I suspect that it's more likely to be</p><p></p><p>There's certainly plenty to read. What seems to be the biggest issue in relation to variability is that when someone is longer term hyperglycaemic there are a number of protective mechanisms that kick in. When they are spiking for a short term, these don't seem to kick in and the oxidative stress caused by the spike continues when glucose levels return to a "normal" level. </p><p></p><p>I have to admit that there's a ton more reading to be done, but the older papers don't seem to like the idea that blood glucose variability has a big part to play, but Hba1C variability does, and more recent work disagrees. There is still a ton of work to be done in this area.</p></blockquote><p></p>
[QUOTE="tim2000s, post: 1105762, member: 30007"] I suspect that it's more likely to be There's certainly plenty to read. What seems to be the biggest issue in relation to variability is that when someone is longer term hyperglycaemic there are a number of protective mechanisms that kick in. When they are spiking for a short term, these don't seem to kick in and the oxidative stress caused by the spike continues when glucose levels return to a "normal" level. I have to admit that there's a ton more reading to be done, but the older papers don't seem to like the idea that blood glucose variability has a big part to play, but Hba1C variability does, and more recent work disagrees. There is still a ton of work to be done in this area. [/QUOTE]
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