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Type 2 Diabetes
Type 2 and Metformin side affects.
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<blockquote data-quote="SimonCrox" data-source="post: 1898999" data-attributes="member: 388174"><p>Sounds like you have given the metformin a fair trial (small dose, modified release) and it is upsetting you. I would go with either something from the SGLT-2 class like dapagliflozin, canagliflozin or empagliflozin or something from the gliptin class linagliptin sitagliptin etc.</p><p>With the SGLT-2s, there is probably not a lot of difference between them cos the trials are all slightly different, but empagliflozin has an effect to protect against heart attack and stroke; you need normal renal function for these to work, but they will help weight, blood pressure and glucose levels, and not make hypo</p><p>The gliptins are older and will also help glucose levels and probably weight and not make hypo; they probably do not avoid heart attacks etc . Linagliptin can be taken whatever renal function and we have a lot of experience with sitagliptin which also looks safe and may go generic soon</p><p>These would be preferable to a sulphonylurea which does not protect against heart attack or stroke, causes weight gain and causes hypos, but cos they are old drugs, they are cheap.</p><p>One could consider pioglitazone which does not cause hypos, and avoids heart attack and stroke if one has had these before, but the weight gain is bothersome and there are other questions about this drug, but it is cheap now.</p><p>As Bulkbiker above said, we are assuming that you have tried diet and exercise and not getting where you want to be.</p><p>Best wishes</p></blockquote><p></p>
[QUOTE="SimonCrox, post: 1898999, member: 388174"] Sounds like you have given the metformin a fair trial (small dose, modified release) and it is upsetting you. I would go with either something from the SGLT-2 class like dapagliflozin, canagliflozin or empagliflozin or something from the gliptin class linagliptin sitagliptin etc. With the SGLT-2s, there is probably not a lot of difference between them cos the trials are all slightly different, but empagliflozin has an effect to protect against heart attack and stroke; you need normal renal function for these to work, but they will help weight, blood pressure and glucose levels, and not make hypo The gliptins are older and will also help glucose levels and probably weight and not make hypo; they probably do not avoid heart attacks etc . Linagliptin can be taken whatever renal function and we have a lot of experience with sitagliptin which also looks safe and may go generic soon These would be preferable to a sulphonylurea which does not protect against heart attack or stroke, causes weight gain and causes hypos, but cos they are old drugs, they are cheap. One could consider pioglitazone which does not cause hypos, and avoids heart attack and stroke if one has had these before, but the weight gain is bothersome and there are other questions about this drug, but it is cheap now. As Bulkbiker above said, we are assuming that you have tried diet and exercise and not getting where you want to be. Best wishes [/QUOTE]
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