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Undiagnosed: Numbness After Consuming Carbohydrates
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<blockquote data-quote="J_Eicher" data-source="post: 1891638" data-attributes="member: 491592"><p>Hi [USER=468501]@DionneT[/USER] </p><p></p><p>I checked with my husband, and he said he checked those SNPs - I also only have one heterozygous mutation there. </p><p></p><p>Ah, I thought insulin took a bit longer than that to kick in. Maybe I should consider redoing the OGTT again then, but demand insulin measurements at each interval - which they failed to do as I'd requested the first time, gah! I have my own BG monitor at home, so I knew my sugar was fine... it was the insulin sensitivity that concerned me (and still does). Also, re my symptoms, I'm never without the sensory issue, but it goes from a non-painful tingling/crawling, to feeling like I have a cheese grater running over my skin, and a million ants biting me (upper thighs are excruciating). The spasms/cramps and twitching are on and off for me (they seem unrelated to the other flare-up patterns), and come and go as they please, but they're not severe. </p><p></p><p>Hmmm, I've heard of a few people struggling with viral infections prior to onset. There are some suggestions in the literature that viruses like HSV/CMV/EBV can migrate to peripheral nerves and remain active there chronically, but it remains contentious. Have you had viral PCR done to check for active viruses?</p><p></p><p>You mentioned antibiotics... not fluoroquinolones like ciprofloxacin (Cipro), levofloxacin (Levaquin), moxifloxacin (Avelox) by any chance? Those are well-known nerve destroyers. [USER=468700]@ChetRoi[/USER] I noticed that you mentioned regular antibiotic use as well. Again, it might be worth doing a stool analysis to check for dysbiosis as well (both of you), as this is commonly triggered by antibiotics, which can lead to lipopolysaccharide toxemia and other gut-related pathologies. Just throwing some ideas out... you never know. <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /></p></blockquote><p></p>
[QUOTE="J_Eicher, post: 1891638, member: 491592"] Hi [USER=468501]@DionneT[/USER] I checked with my husband, and he said he checked those SNPs - I also only have one heterozygous mutation there. Ah, I thought insulin took a bit longer than that to kick in. Maybe I should consider redoing the OGTT again then, but demand insulin measurements at each interval - which they failed to do as I'd requested the first time, gah! I have my own BG monitor at home, so I knew my sugar was fine... it was the insulin sensitivity that concerned me (and still does). Also, re my symptoms, I'm never without the sensory issue, but it goes from a non-painful tingling/crawling, to feeling like I have a cheese grater running over my skin, and a million ants biting me (upper thighs are excruciating). The spasms/cramps and twitching are on and off for me (they seem unrelated to the other flare-up patterns), and come and go as they please, but they're not severe. Hmmm, I've heard of a few people struggling with viral infections prior to onset. There are some suggestions in the literature that viruses like HSV/CMV/EBV can migrate to peripheral nerves and remain active there chronically, but it remains contentious. Have you had viral PCR done to check for active viruses? You mentioned antibiotics... not fluoroquinolones like ciprofloxacin (Cipro), levofloxacin (Levaquin), moxifloxacin (Avelox) by any chance? Those are well-known nerve destroyers. [USER=468700]@ChetRoi[/USER] I noticed that you mentioned regular antibiotic use as well. Again, it might be worth doing a stool analysis to check for dysbiosis as well (both of you), as this is commonly triggered by antibiotics, which can lead to lipopolysaccharide toxemia and other gut-related pathologies. Just throwing some ideas out... you never know. :) [/QUOTE]
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