• Guest, the forum is undergoing some upgrades and so the usual themes will be unavailable for a few days. In the meantime, you can use the forum like normal. We'd love to know what you think about the forum! Take the 2025 Survey »

Type 1 Use of Forxiga with Type 1

Annie H

Annie H

Newbie
I have been Type 1 for over 40 years and generally very well. I was struggling to maintain a healthy weight and stable blood sugar. I was prescribed Forxiga which was amazing I got my weight down to recommended level, had no side effects and blood sugars stabilised. My doctor has now said I must stop the Forxiga, my blood sugars are so up and down and my weight has gone back on. Can anyone explain the risks that taking Forxiga might bring as I now feel less well and frustrated I cannot maintain as good diabetic control as I was achieving with insulin and Forxiga
 
Hi @Annie H - I'm not sure how much assistance you'll get with this one. Your specialist has been using Forxiga off label as it's not currently on the list of drugs for T1. It's also not been around all that long, so there isn't good data on the long term effects of its use, either in T1D or T2D.

Given that the way it works is to cause the kidneys to extract more glucose to be excreted in urine, I'd be concerned that long term use may have an effect on the kidneys.

Sorry we can't be more helpful.
 
Yes, the use of dapagliflozin in T1DM is fiddly (sorry - that is not that helpful).
So, ever since this class was introduced, there have been small trials in T1DM; one wonders if the diabetic person would lose weight, and theoretically, by making one pee out the glucose when blood levels high, it might improve glucose control.
The trial results are variable, but I think a recent dapaglflozin trial in T1DM was positive. The reason that one is scared by mixing the two, is that diabetic ketoacidosis seems to occur more commonly when mixing the two - even when one is aware of the possible problem and patietns are told about it, DKA is still significantly more common; and it is an odd variety of DKA with relatively normal glucose elvels (euglycaemic DKA).
Regarding kidney function, the CANVAS studies and MEPA-REG (I think) showed less (not more) renal impairment with these drugs.
At the end of the day, one must look at the individual; if one can review the benefits (which seem better than average in you) versus the side effects (no genital thrush, and know to test ketones if not feeling right), then one can come up with a plan; one is allowed to go off license, but one should be clear that one is doing this, and the continual questioning by other health care professionals and pharamacists (who do have your best interests at heart) are xceptionally painful.
Best wishes
 
Back
Top