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Message: <blockquote data-quote="plantae" data-source="post: 2573338" data-attributes="member: 565464"><p>The B vitamins are water soluble but they're a bit different from other water soluble vitamins. Normally excess amounts of water soluble vitamins are quickly expelled by your body because they're not stored, unlike fat soluble vitamins. But, the B group is a bit different because although they're not fat soluble they're stored in your liver. So, for a person not on medication the chances of a vitamin B12 deficiency is small (because the body stores it even though it's water soluble). That said, I do not know how metformin -- or other drugs for that matter -- might change this. It's known that other drugs can deplete B reserves so it's not unfeasible that metformin could do the same thing. A deficiency in B12 is not something I'd personally take lightly. As for how long it might take for levels to increase back to acceptable levels... no idea. Blood tests will tell you that, and that's something you need to do and do with your doctor. Don't ignore it though. There's no set time</p></blockquote><p></p>

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