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Was Told By A Doctor To Increase My Carbs
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<blockquote data-quote="CrumblingWall" data-source="post: 2085630" data-attributes="member: 494805"><p>What also interests me if the following - if one takes OGTT during low carb diet, what happens? Will BG rise sharply upwards because of 1) or 2), or both</p><p></p><p>1) Actual insulin resistance induced by ketogenic state - glucose is spared for essential organs while all other cells run on ketones. So, glucose clearance is significantly slowed down, hence we see large peak, and then delayed glucose clearance at say 3 hours mark instead of 2.</p><p></p><p>2) Insulin deficiency. Caused by pancreas being in park mode - no demand for glucose clearing means pancreas is putting out bare minimum, and does not have much stored for phase 1 response. When presented with a dump of glucose, it takes time for it to actually produce required insulin to clear the glucose. It is much slower than just squirting out insulin pre-made, which means glucose builds up in the blood for longer, and looks like insulin resistance. Eventually, phase 2 response happens, and glucose goes back to normal or even hypo because pancreas is working intensely to clear sudden load of glucose it was not expecting...</p><p></p><p>Endocrinologist mentioned insulin resistance, but am wondering how it can be that. My c-peptide is consistently on low side, not really showing resistance. I am leaning towards 2) ...</p></blockquote><p></p>
[QUOTE="CrumblingWall, post: 2085630, member: 494805"] What also interests me if the following - if one takes OGTT during low carb diet, what happens? Will BG rise sharply upwards because of 1) or 2), or both 1) Actual insulin resistance induced by ketogenic state - glucose is spared for essential organs while all other cells run on ketones. So, glucose clearance is significantly slowed down, hence we see large peak, and then delayed glucose clearance at say 3 hours mark instead of 2. 2) Insulin deficiency. Caused by pancreas being in park mode - no demand for glucose clearing means pancreas is putting out bare minimum, and does not have much stored for phase 1 response. When presented with a dump of glucose, it takes time for it to actually produce required insulin to clear the glucose. It is much slower than just squirting out insulin pre-made, which means glucose builds up in the blood for longer, and looks like insulin resistance. Eventually, phase 2 response happens, and glucose goes back to normal or even hypo because pancreas is working intensely to clear sudden load of glucose it was not expecting... Endocrinologist mentioned insulin resistance, but am wondering how it can be that. My c-peptide is consistently on low side, not really showing resistance. I am leaning towards 2) ... [/QUOTE]
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