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Message: <blockquote data-quote="Roggg" data-source="post: 2376694" data-attributes="member: 489176">For what it;'s worth, this is a pretty good meta-analysis quantifying the effects of metformin:<a href="https://care.diabetesjournals.org/content/diacare/35/2/446.full.pdf" target="_blank">https://care.diabetesjournals.org/content/diacare/35/2/446.full.pdf</a>Short story:  Metformin as a monotherapy lowers HBA1c by about 1.12%.  This does NOT mean dropping the HBA1c by 1.12% of what it was prior.  HBA1c is already measured as a percent (in many places..there are other measures), so this is like going from 8.12% to 7.0%.  Metformin combined with other treatments had less effect.  I would call 1.12% pretty modest given that my A1C has been as high as 10% before.  It's enough to treat borderline diabetics or pre-diabetics into normal readings but wont be enough alone for even intermediate cases.1.12% A1c is about equivalent to a drop in average glucose levels of about 1.7mmol/l or in the neighbourhood of 35mg/dl.  Hope this helps.</blockquote>

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