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What is the relationship between mmol/l and mmol/mol
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<blockquote data-quote="phoenix" data-source="post: 941707" data-attributes="member: 12578"><p>Your HbA1c is a measurement of glucose bound to haemoglobin. Glucose molecules in the blood may bind through a chemical reaction to the red blood cells. The more glucose present, the more likely that they will become attatched. Once completely bound (glycated) the glucose stays attached for the life of the blood cell which is around 3 months. The HbA1c measures the proportion of glucose molecules bound to haemoglobin at the time of testing</p><p></p><p>The measurement until recently was expressed as the percentage of glycated haemoglobin in a quantity of haemoglobin.(so you will see many people writing 5%, 6%,7% etc for their HbA1c measurement)</p><p>In the UK and some other countries this has been changed following recent standardisation to a 'proper' SI unit of mmol of HbA1c (glycated haemoglobin) per mol of haemoglobin (mmol/mol).</p><p></p><p>Since the glycated haemoglobin has arisen over the last 2-3months this measurement gives an indication of glucose levels over that period. Because of the turnover of red cells, it is weighted somewhat towards levels during the later weeks</p><p></p><p>If red blood glucose levels glycate at an average level, then Hba1c test results may give an indication of what your average glucose levels have been over the last 2-3months (ie if you were continuously testing them) There is an algorithm for this and it's good enough for many people. You can use the converter on this site . The last box is the estimated average glucose <a href="http://www.diabetes.co.uk/hba1c-units-converter.html" target="_blank">http://www.diabetes.co.uk/hba1c-units-converter.html</a></p><p></p><p>However there are people who are not average glycators ( their red cells don't live as long, they have less haemoglobin , for some reason less glucose gets bound etc). Moreover, the algorithm was tested on a fairly limited number of subjects. It is for that reason that the UK doesn't include the estimated average glucose level with results. <a href="http://care.diabetesjournals.org/content/32/1/e11.full" target="_blank">http://care.diabetesjournals.org/content/32/1/e11.full</a></p><p></p><p>Your meter readings just show the amount of glucose in the blood plasma at that moment in time. It is expressed in the UK as mmol per litre of plasma .</p><p>There are 180.1559 g glucose in a mol. (in other parts of the world, including the US and parts of Europe, they use milligrams per decilitre and to convert mmol/l to mg/dl you multiply by 18)</p><p></p><p>This is I think a useful video (though as it is from the US uses % of glycated to non glycated haemoglobin so I've put it after )</p><p>[MEDIA=youtube]MOH33-jFOwo[/MEDIA]</p></blockquote><p></p>
[QUOTE="phoenix, post: 941707, member: 12578"] Your HbA1c is a measurement of glucose bound to haemoglobin. Glucose molecules in the blood may bind through a chemical reaction to the red blood cells. The more glucose present, the more likely that they will become attatched. Once completely bound (glycated) the glucose stays attached for the life of the blood cell which is around 3 months. The HbA1c measures the proportion of glucose molecules bound to haemoglobin at the time of testing The measurement until recently was expressed as the percentage of glycated haemoglobin in a quantity of haemoglobin.(so you will see many people writing 5%, 6%,7% etc for their HbA1c measurement) In the UK and some other countries this has been changed following recent standardisation to a 'proper' SI unit of mmol of HbA1c (glycated haemoglobin) per mol of haemoglobin (mmol/mol). Since the glycated haemoglobin has arisen over the last 2-3months this measurement gives an indication of glucose levels over that period. Because of the turnover of red cells, it is weighted somewhat towards levels during the later weeks If red blood glucose levels glycate at an average level, then Hba1c test results may give an indication of what your average glucose levels have been over the last 2-3months (ie if you were continuously testing them) There is an algorithm for this and it's good enough for many people. You can use the converter on this site . The last box is the estimated average glucose [URL]http://www.diabetes.co.uk/hba1c-units-converter.html[/URL] However there are people who are not average glycators ( their red cells don't live as long, they have less haemoglobin , for some reason less glucose gets bound etc). Moreover, the algorithm was tested on a fairly limited number of subjects. It is for that reason that the UK doesn't include the estimated average glucose level with results. [URL]http://care.diabetesjournals.org/content/32/1/e11.full[/URL] Your meter readings just show the amount of glucose in the blood plasma at that moment in time. It is expressed in the UK as mmol per litre of plasma . There are 180.1559 g glucose in a mol. (in other parts of the world, including the US and parts of Europe, they use milligrams per decilitre and to convert mmol/l to mg/dl you multiply by 18) This is I think a useful video (though as it is from the US uses % of glycated to non glycated haemoglobin so I've put it after ) [MEDIA=youtube]MOH33-jFOwo[/MEDIA] [/QUOTE]
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