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<blockquote data-quote="MEValentijn" data-source="post: 2057495" data-attributes="member: 498395"><p><span style="font-family: 'Arial'">"Drivers" doesn't mean that that they only cause HF, and not vice versa. It also means that they interact with each other to exacerbate the entire situation:</span></p><p>"Thus, epidemiological evidence implies a bidirectional association between HF and T2DM (<em>Figure 1</em>), with one increasing the incidence and worsening the prognosis of the respective other.14"</p><p></p><p></p><p></p><p><span style="font-family: 'Arial'">Indeed it's not known why it happens - but the fact remains that if someone has CHF, they are relying much more upon ketones:</span></p><p><span style="font-family: 'Arial'">"In heart failure, increased uptake of free fatty acids and glucose into the cytosol is uncoupled from mitochondrial uptake and oxidation of free fatty acid and pyruvate, respectively. This provokes accumulation of metabolic intermediates in the cytosol which can trigger lipo- and glucotoxicity. Instead, utilization of ketone bodies is increased in heart failure.</span>"</p><p></p><p><span style="font-family: 'Arial'">If your interest in posting is to quibble about the distinction between causation and correlation, please find a more relevant venue. Out of respect to the original poster, try to stay relevant to their concerns.</span></p></blockquote><p></p>
[QUOTE="MEValentijn, post: 2057495, member: 498395"] [FONT=Arial]"Drivers" doesn't mean that that they only cause HF, and not vice versa. It also means that they interact with each other to exacerbate the entire situation:[/FONT] "Thus, epidemiological evidence implies a bidirectional association between HF and T2DM ([I]Figure 1[/I]), with one increasing the incidence and worsening the prognosis of the respective other.14" [FONT=Arial]Indeed it's not known why it happens - but the fact remains that if someone has CHF, they are relying much more upon ketones: "In heart failure, increased uptake of free fatty acids and glucose into the cytosol is uncoupled from mitochondrial uptake and oxidation of free fatty acid and pyruvate, respectively. This provokes accumulation of metabolic intermediates in the cytosol which can trigger lipo- and glucotoxicity. Instead, utilization of ketone bodies is increased in heart failure.[/FONT]" [FONT=Arial]If your interest in posting is to quibble about the distinction between causation and correlation, please find a more relevant venue. Out of respect to the original poster, try to stay relevant to their concerns.[/FONT] [/QUOTE]
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