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What's the test to identify the large, fluffy LDL component?
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<blockquote data-quote="phoenix" data-source="post: 677927" data-attributes="member: 12578"><p>In the past [USER=97664]@jack412[/USER], there was a tendency to assure people that high LDL doesn't matter if you are low carb ,especially if you have low trigs because they will all be large and fluffy.( you could find several examples on this forum, here's one from some time ago but it's typical of what was often written '<em>With low trigs and high HDL the LDL molecules are larger, fluffy and non-dangerous, it's the small VLDL which is a danger signal. Trigs/HDL ratio should be below 3 in US numbers, I think that translates to below 1.2 or 1.3 in UK numbers</em>. <a href="http://www.diabetes.co.uk/forum/threads/carbs-the-lowdown.4542/#post-31363" target="_blank">http://www.diabetes.co.uk/forum/threads/carbs-the-lowdown.4542/#post-31363</a> I agree with him about monounsaturated fats ! )</p><p></p><p></p><p>You don't necessarily lower your VLDL in any case on a low carb diet. Krause is the researcher who found this with dairy but then was surprised when he found it not to be the case on his combined beef and dairy trial where ApoB rose <a href="http://ctsi.ucsf.edu/news/about-ctsi/link-between-meat-" target="_blank">http://ctsi.ucsf.edu/news/about-ctsi/link-between-meat-</a></p><p></p><p>Dayspring (and Attia) say that the number not the type of particle matters basically if there are a lot of them they are likely to cause damage. This is what was found when researchers controlled for number rather than just looking at the association between size and artherosclerosis. (and that is also in accord with people who have familial hyperlipidemia who have large fluffy particles People with insulin resistance though are likely to have large numbers of VLDL particles See the comments here</p><p><a href="http://eatingacademy.com/nutrition/the-straight-dope-on-cholesterol-part-iv" target="_blank">http://eatingacademy.com/nutrition/the-straight-dope-on-cholesterol-part-iv</a></p><p>(and I have just found the statement about particle size that Dayspring mentions in his comment It summarises the available evidence </p><p> p 358 <a href="https://www.lipid.org/sites/default/files/articles/expert_panel_paper.pdf" target="_blank">https://www.lipid.org/sites/default/files/articles/expert_panel_paper.pdf</a> )</p><p></p><p>Dayspring also writes of a patient on a paleo/low carb diet whose trigs fell from 78mg/dl to 49mg/dl ( under 150mg/dl is considered norma) l but whose LDL rose from 105mg/dl (2.7mmol/l) to 230mg/d (5.9mmol/l). The trig/HDL ratio is still seemingly ideal</p><p> However, when tested her particle number belied this, it was sky high (99th percentile). This according to him was a risky profile.</p><p><a href="http://www.lecturepad.org/dayspring/lipidaholics/pdf/LipidaholicsCase291.pdf" target="_blank">http://www.lecturepad.org/dayspring/lipidaholics/pdf/LipidaholicsCase291.pdf</a></p></blockquote><p></p>
[QUOTE="phoenix, post: 677927, member: 12578"] In the past [USER=97664]@jack412[/USER], there was a tendency to assure people that high LDL doesn't matter if you are low carb ,especially if you have low trigs because they will all be large and fluffy.( you could find several examples on this forum, here's one from some time ago but it's typical of what was often written '[I]With low trigs and high HDL the LDL molecules are larger, fluffy and non-dangerous, it's the small VLDL which is a danger signal. Trigs/HDL ratio should be below 3 in US numbers, I think that translates to below 1.2 or 1.3 in UK numbers[/I]. [url]http://www.diabetes.co.uk/forum/threads/carbs-the-lowdown.4542/#post-31363[/url] I agree with him about monounsaturated fats ! ) You don't necessarily lower your VLDL in any case on a low carb diet. Krause is the researcher who found this with dairy but then was surprised when he found it not to be the case on his combined beef and dairy trial where ApoB rose [url]http://ctsi.ucsf.edu/news/about-ctsi/link-between-meat-[/url] Dayspring (and Attia) say that the number not the type of particle matters basically if there are a lot of them they are likely to cause damage. This is what was found when researchers controlled for number rather than just looking at the association between size and artherosclerosis. (and that is also in accord with people who have familial hyperlipidemia who have large fluffy particles People with insulin resistance though are likely to have large numbers of VLDL particles See the comments here [url]http://eatingacademy.com/nutrition/the-straight-dope-on-cholesterol-part-iv[/url] (and I have just found the statement about particle size that Dayspring mentions in his comment It summarises the available evidence p 358 [url]https://www.lipid.org/sites/default/files/articles/expert_panel_paper.pdf[/url] ) Dayspring also writes of a patient on a paleo/low carb diet whose trigs fell from 78mg/dl to 49mg/dl ( under 150mg/dl is considered norma) l but whose LDL rose from 105mg/dl (2.7mmol/l) to 230mg/d (5.9mmol/l). The trig/HDL ratio is still seemingly ideal However, when tested her particle number belied this, it was sky high (99th percentile). This according to him was a risky profile. [url]http://www.lecturepad.org/dayspring/lipidaholics/pdf/LipidaholicsCase291.pdf[/url] [/QUOTE]
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