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Message: <blockquote data-quote="Oldvatr" data-source="post: 2343581" data-attributes="member: 196898">I take Gliclazide.  It is designed to increase insulin output from the pancreas so it is a sledgehammer pushing blood glucose into storage against Insulin Resistance.One thing to bear in mind is that it only works when insulin is being demanded by the hormones.  It actually responds to the Amylase enzyme that is triggered when carbs are eaten.  Nothing eaten = no benefit from Glic.  Indeed taking Glic after a meal is counterproductive since the insulin rush will have passed,  So it is best taken about 20 minutes before a meal.  I  realised this and went to TWOMAD to match my doses (originally 4x80mg tabs split 2x2, but now I have only one 40 mg tab taken to cover the main meal in the day, and I eat a standard low carb breakfast that I know does not trigger any significant glucose spike,  You can get Glic in 40mg tabs if that makes meal matching easier, but the Doc will need to split it on the scrip.</blockquote>

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