DSN has told me when blood sugar keeps going up to take 20mg a day until it’s stable again, took one on Wednesday & blood sugar back to normal in 2 hours, took it Thursday & Friday just to be sure, usually it stays stable for a couple of weeks until it rises again, just seems to need to be reminded to release insulin every so often, so frustrating though trying to plan meals & getting to work & back, I carry a lunch bag of food everywhere with meThis must be so frustrating for you. Just wondered if any medics had suggested taking the Gliclazide on alternate days, or more on one day, less the next etc? Not suggesting you do this without medical input, but a family member with type 2 ended up being told to do this by their endocrinologist, as they were having lots of hypo's, and it worked well for them until they were able to come off it completely.
Have a read on bloodsugar101 then MODY, it’s a very interesting read.There has been a lot of mention of MODY.
Both diabetes.co.uk and diabetes.org.uk state that this a variant of diabetes which is characterised by onset before one is 25.
Is this still the case?
Have a read on bloodsugar101 then MODY, it’s a very interesting read.
Apparently very often misdiagnosed & can get it at any age (although genetic defect there since birth), now come to light my dad had raised blood sugar but never diagnosed as diabetic, blood sugar rose to 12.9 yesterday 20mg of gliclazide down to 3.6 within 3 hours, after eating 2 meals, can’t get a referral without seeing my gp, can’t get appointment with gp, feel sick & dizzy today not gone to work
Have a read on bloodsugar101 then MODY, it’s a very interesting read.
Apparently very often misdiagnosed & can get it at any age (although genetic defect there since birth), now come to light my dad had raised blood sugar but never diagnosed as diabetic, blood sugar rose to 12.9 yesterday 20mg of gliclazide down to 3.6 within 3 hours, after eating 2 meals, can’t get a referral without seeing my gp, can’t get appointment with gp, feel sick & dizzy today not gone to work
Thanks, I hadn’t seen that before,Thanks for the pointer.
I assume that you aren't taking Metformin along with the gliclazide?
A search shows that gliclazide is a sulphonylurea.
https://diabetesupdate.blogspot.com/2010/09/diabetes-drug-interactions-can-harm-you.html
Note that I think this is for a different sulphonylurea but it does seem to strike a chord with the problems that you are having.
"Prandin is marketed with the information that it is very short acting--and is out of the body in about 3 hours. I had tried it a few years ago and this seemed to be the case.
What I didn't know--and learned the very hard way--is that this is only true if you take Prandin alone--without Metformin. If you combine the two, it turns out that the Metformin blocks the mechanism in the liver that eliminates Prandin and the drug ends up being much, much more potent."
"It is there that we learn that, over a 4-5 month period, people taking Prandin alone saw their blood fasting blood sugar rise by an of 8 mg/dl, and people taking Metformin alone saw an average drop in their fasting blood sugar of 4.5 mg/dl, but people taking both drugs simultaneously experienced an average decline in fasting blood sugar of 39.2 mg/dl--almost ten times as much as with Metformin alone!"
The whole page is well worth a read (if you haven't read it already) but it seems that over time the drug is not eliminated but keeps building up until there is a violent over reaction which is hard to control.
This feels as though it might map onto a slow increase in hypo risk then strong hypo reaction.
Then you stop the drug, and your BG slowly starts to rise.
Rinse and repeat.
Apologies if you have already covered this.
I am drowning in MODY information at the moment.
I’ve read so much about MODY I’m confused.
Thank you for posting this, think I’m even more confused now,Forgive me, but I haven't read all the way through this thread.
However I have come across a video by Prof Jim Johnson in 2018 which may show why a Low Carb High Fat diet may not work to get T2D's into remission for up as many as 7% of people.
It's quite a long way into that video, but the Prof says that in general the way to make a mouse diabetic is to feed it a high fat diet because the mouse natural diet and their pancreas is so different from a human.
However he did an experiment on live pancreas cells (from dead donors) and found that there were 2 subject pancreas (out of around 30) where there was an insulin response to fatty acids was comparable to that of carbs.
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