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Diabetes Discussion
Type 1 Diabetes
Which is best. More Basal or more Bolus?
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<blockquote data-quote="tim2000s" data-source="post: 1572824" data-attributes="member: 30007"><p>That's exactly what the statement is. Once you get above 7u for a dose, there's a belief that you get slower absorption due to the relative surface area to volume of insulin. At doses of 7u or smaller, you have multiple spheres of insulin and therefore absorb it all much faster. The same would be true for a large bolus. However there has since been evidence that suggests that insulin doesn't diffuse from the tip of the needle in a sphere, but in fact spreads along the collagen matrix parallel to the skin until you reach a certain volume (reckoned to be 100 microlitres) when you also get a perpendicular spread <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692237/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692237/</a></p><p></p><p>This is somewhat backed up in some experimental work done and patents on "Sprinkler Cannulas" for pumps, where the needle had six separate holes. Fast acting insulin absorption was significantly better. </p><p></p><p>A patent: <a href="https://encrypted.google.com/patents/US20130245555?cl=ru" target="_blank">https://encrypted.google.com/patents/US20130245555?cl=ru</a> </p><p></p><p>Some research that demonstrates the benefits: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1246546/pdf/bmjcred00022-0009.pdf" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1246546/pdf/bmjcred00022-0009.pdf</a></p><p></p><p>What do I take from this? All Insulin needles need redesigning, and you might see significantly faster acting Novorapid, Humalog and Apidra if they were available.</p></blockquote><p></p>
[QUOTE="tim2000s, post: 1572824, member: 30007"] That's exactly what the statement is. Once you get above 7u for a dose, there's a belief that you get slower absorption due to the relative surface area to volume of insulin. At doses of 7u or smaller, you have multiple spheres of insulin and therefore absorb it all much faster. The same would be true for a large bolus. However there has since been evidence that suggests that insulin doesn't diffuse from the tip of the needle in a sphere, but in fact spreads along the collagen matrix parallel to the skin until you reach a certain volume (reckoned to be 100 microlitres) when you also get a perpendicular spread [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692237/[/URL] This is somewhat backed up in some experimental work done and patents on "Sprinkler Cannulas" for pumps, where the needle had six separate holes. Fast acting insulin absorption was significantly better. A patent: [URL]https://encrypted.google.com/patents/US20130245555?cl=ru[/URL] Some research that demonstrates the benefits: [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1246546/pdf/bmjcred00022-0009.pdf[/URL] What do I take from this? All Insulin needles need redesigning, and you might see significantly faster acting Novorapid, Humalog and Apidra if they were available. [/QUOTE]
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Which is best. More Basal or more Bolus?
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