Why isn't hyperinsulinemia talked about more

AndBreathe said:

NatJS - I don't know of any means, like there is to test blood glucose, but there are several companies offering lab tests; done by mail order, and often the blood collection is from a finger prick test.

An example of these companies is Blue Horizon, which can be found here: http://bluehorizonmedicals.co.uk/ep...b91-b6f9-4318-864a-f492cbae7827/Products/INSU

There are several alternatives, if you feel like consulting Dr Google. Prices vary, and most of these providers do offers from time to time. You don't need a GP referral to use these services, but of course, you would need to foot the bill yourself.

I have no relationship with Blue Horizon.

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My wife has used Medichecks as well as Blue Horizon and found them to be very good, they are also have a partnership with Thyroid UK:

https://www.medichecks.com/tests/insulin

https://www.medichecks.com/tests/insulin-resistance-test

Great to find a thread with other people who follow the ideas of Joseph Kraft, Jason Fung and Ivor Cummins!
I read the Obesity Code 12 months ago. More recently I have discovered Ivor Cummins and Joseph Kraft. For 12 months I have focussed on strategies to lower my insulin levels, but the only measurements I have got to go on are my blood sugar levels (blood glucose meter measurements and HbA1c). I have done good things for my glucose levels but I know nothing about what impact that has had on my baseline insulin or my insulin response after consuming carbs (the speed of the rise and fall). I am in New Zealand and getting an insulin assay such as Joseph Kraft did is not something that is recognised as relevant, therefore it's not provided by our medical system. Although it might be possible to ask for it and pay for it myself.
Does anyone here have measurements of their fasting insulin? Or even better, how their insulin levels rise and fall in the hours after consuming 75g or 100g of glucose? I'd love to know which of Joseph Kraft's patterns I fall into, and then find out if I can improve that pattern over years through minimising carb intake and intermittent fasting. If I can't measure it how can I know whether I am making a difference to it?
Also how is insulin resistance directly measured or indirectly estimated? Does anyone here have measures of their insulin resistance? How was it done? What are the units? Again how can we know whether our actions are effective if we have no measures to monitor?

More discussions on the issue...

Hyperinsulinemia: a Cause of Obesity? (May 2017)
https://link.springer.com/article/10.1007/s13679-017-0261-z

Banting lecture 2011: hyperinsulinemia: cause or consequence?
https://www.ncbi.nlm.nih.gov/pubmed/22187369

kokhongw said:

More discussions on the issue...

Hyperinsulinemia: a Cause of Obesity? (May 2017)
https://link.springer.com/article/10.1007/s13679-017-0261-z

Banting lecture 2011: hyperinsulinemia: cause or consequence?
https://www.ncbi.nlm.nih.gov/pubmed/22187369

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They seek him here, they seek him there. they seek that elusive obesogen everywhere! I like it! Keep those blasted obesogens away from me, please.

This is a good chicken and egg story. The eternal triangle. HI vs HL vs T2D which comes first. The first article is a good read, but until they identify the obesogen then how are they going to breed the genetically modified mice to experiment on?

Where can I get some of that somatostatin from? Sounds like it could be the only statin worth taking.
Not sure what this throw away line means for those of us using LCHF

<<<<We have previously shown that the hypersecretion of insulin following chronic exposure to elevated fatty acids impairs the ability of the ß-cell to adequately respond to acute nutrient stimulation>>>>

Is this the pate-de-foie-gras syndrome? Poor force fed genetically altered mice. But it probably describes the Pizza Effect quite well. Looking at Ref [91] does not help explain how they made this startling conclusion

Oldvatr said:

Here is an article that apparently describes a simple method to use at home to approximate an insulin resistance measurement. It is based on the OGTT method, but has a relatively simple formula involving taking timing measurements.

Warning: the article is not free, and a one off charge applies.
https://www.sciandmed.com/sm/journalviewer.aspx?issue=1072&article=844

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Further research into this topic has revealed the following studies, one of which reveals a formula, the second needs upfront payment to see it.
https://www.ncbi.nlm.nih.gov/pubmed/12629079

https://www.ncbi.nlm.nih.gov/pubmed/17942180

Element137 said:

I have done a fair bit of reading on this too, Ivor Cummins very good at explaining the role of insulin resistance, also Ted Naiman from the US - from my understanding, I believe the challenge to most T2's is control of Insulin levels rather than Blood Glucose level, but no easy way to measure insulin level - however, bring BG down ( very easy to measure ) then insulin level comes down, insulin level down means body can burn fat, burn fat means reduced fat in adipose cells, reduced fat in adipose cells means reduced insulin resistance= body able to regulate BG better - its an elegant process.

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I agree with everything you say here. Ted Naiman is excellent too despite his eccentric and informal communication style. I have been following the strategy you outline to bring BG down and burn fat for 12 months now and had some success, initially with weight loss and latterly with lower average BG. Now I'm at a fairly stable state re BMI=22.5 and BG mostly between 4-6 when it used to be between 5-8 mmol/L. The work of Joseph Kraft shows that normal BG response does not necessarily mean a normal insulin response however. So however elegant the process is, I now need feedback re insulin levels to know where I am on the hyperinsulinemia spectrum. Have I normalised my insulin response or not? Do I still have a way to go? Is it possible to make further progress using LCHF, fasting and exercise?