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<blockquote data-quote="Oldvatr" data-source="post: 1761938" data-attributes="member: 196898"><p>It is not a heart med per se. It is contraindicated in cases where lactic acidosis would be problematic</p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971167/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971167/</a></p><p></p><p>The CVE effects noted are more plumbing related than pump, so it is the arteries that seem to benefit. So no, not a heart specific med at all.</p><p><a href="https://www.news-medical.net/news/20131107/Study-finds-few-beneficial-effects-of-metformin-drug-for-cardiovascular-disease-in-people-without-diabetes.aspx" target="_blank">https://www.news-medical.net/news/20131107/Study-finds-few-beneficial-effects-of-metformin-drug-for-cardiovascular-disease-in-people-without-diabetes.aspx</a></p><p>There was a meta analysis report published last year that demonstrated the increased longevity effects of Metformin, but I no longer have the link to it. </p><p></p><p>There is also a T1D specific study in 2017</p><p><a href="https://www.nature.com/articles/nrendo.2017.116" target="_blank">https://www.nature.com/articles/nrendo.2017.116</a></p><p><a href="http://www.diabetesincontrol.com/ada-cardiovascular-benefits-seen-with-long-term-metformin-use-in-adults-with-type-1-diabetes/" target="_blank">http://www.diabetesincontrol.com/ada-cardiovascular-benefits-seen-with-long-term-metformin-use-in-adults-with-type-1-diabetes/</a></p><p></p><p>And an AHA report (?) on heart related effects from 2014</p><p><a href="http://jaha.ahajournals.org/content/3/6/e001202" target="_blank">http://jaha.ahajournals.org/content/3/6/e001202</a></p><p></p><p>And another USA study</p><p><a href="http://care.diabetesjournals.org/content/26/1/243" target="_blank">http://care.diabetesjournals.org/content/26/1/243</a></p><p></p><p>Edit to add an interesting study specific to the Heart Failure contraindication</p><p><a href="https://www.sciencedirect.com/science/article/pii/S0019483217301943" target="_blank">https://www.sciencedirect.com/science/article/pii/S0019483217301943</a></p><p></p><p>Also the AHA are currently re-evaluating Metformin for repurposing as a general heart drug, thus removing this contraindication. Not yet a NICE guideline, but watch this space......</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 1761938, member: 196898"] It is not a heart med per se. It is contraindicated in cases where lactic acidosis would be problematic [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971167/[/URL] The CVE effects noted are more plumbing related than pump, so it is the arteries that seem to benefit. So no, not a heart specific med at all. [URL]https://www.news-medical.net/news/20131107/Study-finds-few-beneficial-effects-of-metformin-drug-for-cardiovascular-disease-in-people-without-diabetes.aspx[/URL] There was a meta analysis report published last year that demonstrated the increased longevity effects of Metformin, but I no longer have the link to it. There is also a T1D specific study in 2017 [URL]https://www.nature.com/articles/nrendo.2017.116[/URL] [URL]http://www.diabetesincontrol.com/ada-cardiovascular-benefits-seen-with-long-term-metformin-use-in-adults-with-type-1-diabetes/[/URL] And an AHA report (?) on heart related effects from 2014 [URL]http://jaha.ahajournals.org/content/3/6/e001202[/URL] And another USA study [URL]http://care.diabetesjournals.org/content/26/1/243[/URL] Edit to add an interesting study specific to the Heart Failure contraindication [URL]https://www.sciencedirect.com/science/article/pii/S0019483217301943[/URL] Also the AHA are currently re-evaluating Metformin for repurposing as a general heart drug, thus removing this contraindication. Not yet a NICE guideline, but watch this space...... [/QUOTE]
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