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Diabetes Discussion
Type 1 Diabetes
Wrong Diagnosis?
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<blockquote data-quote="catapillar" data-source="post: 1757799" data-attributes="member: 32394"><p>This is not correct. A positive antibody test means you are definitely type 1. But a negative antibody test doesn't mean you aren't type 1. About 25% of type 1s are antibody negative. Either because we haven't identified the antibodies that they have yet, or because the longer you wait between autoimmune attack and testing the less likely you are to have antibodies. If the beta cells are all dead and there's nothing left for the antibodies to kill they aren't going to hang around twiddling their thumbs on the off chance someone is going to test for them.</p><p></p><p>Exeter hospital do genetic testing for MODY. Do you have a strong family history of diabetes, parents, grandparents, uncles/ aunts and brothers /sisters with diabetes? Many patients with MODY find it can be controlled with Gliclazide and no need for insulin. It's not normally managed just with metformin though.</p></blockquote><p></p>
[QUOTE="catapillar, post: 1757799, member: 32394"] This is not correct. A positive antibody test means you are definitely type 1. But a negative antibody test doesn't mean you aren't type 1. About 25% of type 1s are antibody negative. Either because we haven't identified the antibodies that they have yet, or because the longer you wait between autoimmune attack and testing the less likely you are to have antibodies. If the beta cells are all dead and there's nothing left for the antibodies to kill they aren't going to hang around twiddling their thumbs on the off chance someone is going to test for them. Exeter hospital do genetic testing for MODY. Do you have a strong family history of diabetes, parents, grandparents, uncles/ aunts and brothers /sisters with diabetes? Many patients with MODY find it can be controlled with Gliclazide and no need for insulin. It's not normally managed just with metformin though. [/QUOTE]
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