• Guest, the forum is undergoing some upgrades and so the usual themes will be unavailable for a few days. In the meantime, you can use the forum like normal. We'd love to know what you think about the forum! Take the 2025 Survey »

Can Metformin HCL 1000mg cause vitamin B12 deficiency?

C

cmx9

Member
Is this something I should be worried about? I brought this up with my GP and he blew me off, saying vitamin B12 levels can't be affected by Metformin. Is he wrong?


Is it in my best interest to buy an at-home b12 monitoring kit? Is that even a thing I can buy for myself?
 
cmx9 said:
Is this something I should be worried about? I brought this up with my GP and he blew me off, saying vitamin B12 levels can't be affected by Metformin. Is he wrong?


Is it in my best interest to buy an at-home b12 monitoring kit? Is that even a thing I can buy for myself?
Click to expand...
Your GP is wrong.
Copied from the leaflet (https://www.geneesmiddeleninformatiebank.nl/bijsluiters/h128396_piluk.pdf):

Common (may affect up to 1 in 10 people) • changes in taste • decreased or low vitamin B12 levels in the blood (symptoms may include extreme tiredness (fatigue), a sore and red tongue (glossitis), pins and needles (paraesthesia) or pale or yellow skin). Your doctor may arrange some tests to find out the cause of your symptoms because some of these may also be caused by diabetes or due to other unrelated health problems.

Instead of buying a testing kit (no idea if this is possible), I'd show him the leaflet and ask for B12 to be included in your next blood test.
 
I bought a home test for B12 as I had burning tongue syndrome. The results were that I wasn't deficient. I told my GP and he said the tests you buy for B12 aren't always reliable. He did another which did indeed show a deficiency.

So yes, metformin can deplete your B12 levels and no, I wouldn't waste money on buying your own test.
 
It is very very well documented that Metformin depletes B12, and even iron and calcium. Supplementation with calcium is not recommended unless the doctor recommends to do so. It’s complicated. Supplementing with iron would probably only matter if you are vegetarian or vegan. B12 supplementation also depends on these factors. If you are older or don’t eat meat, you will almost definitely need B12. It’s vital. I get tested for B12 every time I do bloods. It comes with Folate or without. Not everyone needs Folate, ask dr again. Dr’s are there to help sick people not to keep us well. Thats the sad and wrong part in this World. The self care is up to us. Learn as much as you can about your own disease and be as active as you can in getting opinions of others who have this attitude. Which is what you’re doing now and thats great!
 
GPs are not the best people to ask about any vitamin deficiency. Mine told me that B12 is poisonous if you take it in supplements!!
 
fumanchu said:
GPs are not the best people to ask about any vitamin deficiency. Mine told me that B12 is poisonous if you take it in supplements!!
Click to expand...

Crazy! Several doctors have agreed with me on the B12 and tested and found without supplementation, B12 is too low. Neuropathy gets very bad without B12 if I don’t supplement and energy too. I’m amazed! Now my doctors recommend B12. Get another doctor! You’s sounds bad.
 
I started on Metformin in August last year and even after 3 month my B12 had reduced. My doctor included it automatically in the blood panel. So I take a supplement now. I have my next blood panel in two weeks. Curious how my body is doing in general, but I was surprised that B12 reduction - no real deficiency yet - showed up so quickly as most sources talk more long term impact.
 
I have been on 1000mg metformin twice daily (told to take with food) since I was diagnosed with type 2 in 2006. I don't know if the metformin had anything to do with my low B12, or if it was something to do with my diet, or the many medications I take to control my myeloma.

Just recently I was asked to repeat a routine blood test to confirm that my B12 was within acceptable levels. Having had the blood test I received a text from my GP practice stating my B12 was rather on the lower end to spectrum, and I love this bit, "you are not eating enough red meat, or drinking enough milk"! o_O I love red meat and I drink milk almost by the gallon. When I read the text to my wife, she nearly fell to the floor in hysterics.

The serious part of this for me, was that I was unaware low consumption of red meat and milk could have this affect on my B12 levels. I know taking a B12 supplement.
 
Grandadfatboy said:
I have been on 1000mg metformin twice daily (told to take with food) since I was diagnosed with type 2 in 2006. I don't know if the metformin had anything to do with my low B12, or if it was something to do with my diet, or the many medications I take to control my myeloma.

Just recently I was asked to repeat a routine blood test to confirm that my B12 was within acceptable levels. Having had the blood test I received a text from my GP practice stating my B12 was rather on the lower end to spectrum, and I love this bit, "you are not eating enough red meat, or drinking enough milk"! I love red meat and I drink milk almost by the gallon. When I read the text to my wife, she nearly fell to the floor in hysterics.

The serious part of this for me, was that I was unaware low consumption of red meat and milk could have this affect on my B12 levels. I know taking a B12 supplement.
Click to expand...
Maybe this is american-only problem but diabetics can drink milk? Whenever I drink anything that's not water or a sugar free soda, my blood sugar spikes to 250. Everything we have has added sugar and I'm worn out trying to find foods that aren't actively out to hospitalize me.


I should also say that I'm very poor and that my doctor is the only person I could find close to where I live that does reduced costs for visits. I guess I get what I pay for if he's confident that b12 isn't lowered by metformin. Love american healthcare!
 
cmx9 said:
Maybe this is american-only problem but diabetics can drink milk?
Click to expand...
Normally yes, depending on the quantity!
There are more carbohydrates in skim milk than full fat milk.
Cream is even lower carbohydrate.
Cheese is also good as some carbohydrate is fermented out during production.
 
LittleGreyCat said:
Normally yes, depending on the quantity!
There are more carbohydrates in skim milk than full fat milk.
Cream is even lower carbohydrate.
Cheese is also good as some carbohydrate is fermented out during production.
Click to expand...
Double cream diluted with water makes an acceptable milk substitute. Personally I just use cream full strength but that can get expensive.
 
cmx9 said:
Is this something I should be worried about? I brought this up with my GP and he blew me off, saying vitamin B12 levels can't be affected by Metformin. Is he wrong?


Is it in my best interest to buy an at-home b12 monitoring kit? Is that even a thing I can buy for myself?
Click to expand...
 
yes it can cause an deficiency of B12 after years of taking Metformin , after 20 yrs of taking Metformin i was put on an vitamin B12 injections every 3 months , for the past 10 yrs .
 
cmx9 said:
Is this something I should be worried about? I brought this up with my GP and he blew me off, saying vitamin B12 levels can't be affected by Metformin. Is he wrong?


Is it in my best interest to buy an at-home b12 monitoring kit? Is that even a thing I can buy for myself?
Click to expand...
Winner for being aware.
Hug for the doctor being so misinformed.

Like others I asked for B12 testing to be added to my blood works ...no problem

Now gets tested each time.

A fair few posts regarding the issue.

I posted this.

I found the lady in question on YouTube not long after finding out how I could be impacted (I was )

I'd recommend anyone over sixty or taking Metformin gave it a moment of their time.
I'd even go so far as saying if they have anyone they love in that category, it's worth the watch of the film I link to.

Good luck finding a doc who understands Metformin properly.

Oops! We ran into some problems.

www.diabetes.co.uk www.diabetes.co.uk
 
Back
Top