Duodenumumumumum........ouch!

[LittleGreyCat]

Having seen a link in the Mirror then tracked back to a NewsBot posting, I thought I would start a specific thread.

http://www.diabetes.co.uk/forum/thr...to-treat-type-2-diabetes.128749/#post-1606599

The study seems to implicate the duodenum lining in Insulin Resistance and giving it a good kicking seems to improve short term BG control in T2s.

Interesting because there seems to be very little discussion of the role of the duodenum in BG regulation.

I am now wondering if it turns out that one has IR but there isn't fat around the liver and pancreas, if the duodenum may be the culprit. If so, how do you check? Apart from searing the lining with 90 C water and seeing if that improves things?

 

[Mr_Pot]

I think the important phrase is "gut signalling". I didn't get the impression that the treatment tackled IR directly, more likely the triggering of insulin response, but I am guessing.

 

[DCUKMod]

Having seen a link in the Mirror then tracked back to a NewsBot posting, I thought I would start a specific thread.

http://www.diabetes.co.uk/forum/thr...to-treat-type-2-diabetes.128749/#post-1606599

The study seems to implicate the duodenum lining in Insulin Resistance and giving it a good kicking seems to improve short term BG control in T2s.

Interesting because there seems to be very little discussion of the role of the duodenum in BG regulation.

I am now wondering if it turns out that one has IR but there isn't fat around the liver and pancreas, if the duodenum may be the culprit. If so, how do you check? Apart from searing the lining with 90 C water and seeing if that improves things?

I know a bit about this study, having heard a couple of presentations on it, along the way. I don't qualify to take part, although I know they are trying hard to achieve their threshold number of participants.

 

[Guzzler]

Lustig, in one of his lectures alludes to this. It is thought that the duodenum and, indeed, the gut as a whole plays a far more important role in the metabolism than previously thought. He mentions (if memory serves, and it often doesn't) that hormones are released in the upper part of the doudenum that affect saity and hunger and quotes the alimentary system's 'second brain' roles in the metabolism as a whole. Fascinating stuff.

 

[LittleGreyCat]

I know a bit about this study, having heard a couple of presentations on it, along the way. I don't qualify to take part, although I know they are trying hard to achieve their threshold number of participants.

I wonder if this is something this site could promote?

I would be tempted to give it a go if I lived nearer Nottingham. I assume you need to live near because of the number of visits required to participate.

 

[DCUKMod]

I wonder if this is something this site could promote?

I would be tempted to give it a go if I lived nearer Nottingham. I assume you need to live near because of the number of visits required to participate.

Sorry, LittleGreyCat, I am not clear what it is you feel the site could promote?

Whilst this phase of the Revita Study is based out of Nottingham, work has also been done on it at King's in London, but I can't for the life of me remember if that is still ongoing. I don't know if Kings would work for you/

If you are seriously interested in the piece of work, you could always get in contact. The worst they could say would be "Thanks, but no thanks"?

 

[archersuz]

Apart from searing the lining with 90 C water and seeing if that improves things?

Not sure I fancy that!

 

[LittleGreyCat]

Sorry, LittleGreyCat, I am not clear what it is you feel the site could promote?

Whilst this phase of the Revita Study is based out of Nottingham, work has also been done on it at King's in London, but I can't for the life of me remember if that is still ongoing. I don't know if Kings would work for you/

If you are seriously interested in the piece of work, you could always get in contact. The worst they could say would be "Thanks, but no thanks"?

You said that the Nottingham study was having trouble getting the required quota of participants (if I understood).

Perhaps a banner heading to let everyone know that there is a need for people to participate.

You have one at the moment for Royal Holloway.

 

[LittleGreyCat]

Not sure I fancy that!

I'm not sure I fancy the sedation then stuff being fed down your throat and through your stomach to the duodenum. Or them pulling it back out again afterwards. However if it does dramatically reduce IR then it might be worth the hassle and discomfort.