Hey All, took alpha-lipoic for years and just stopped for no reason, really.....In the Fall I started having major numbness, tingling in both hands. Got where it would wake me at night and Tylenol did nothing to ease the associated pain. Started R-Alpha Lipoic in February and within a month I realized I no longer had the hand problem! Go figure! So, I am a believer and yes, I take Metformin - in the process of weaning off it as making such good progress with blood sugars. For what it's worth, I will continue taking it due to the quality of life it affords me the R-ALA that is. Cheers/L