FDA alert about SGLT2 Inhibitors

[Irene Banting]

I am type one myself but just came across this alert:-

https://www.google.com/url?sa=t&sou...cm617360.htm&usg=AOvVaw1YKx8E88_Vu7fQP5BxfdxY

 

[Guzzler]

There have been a coupla threads about SGLT2 inhibitors wrt to low carb diets and the risk of DKA. I have to admit that if/when I have to add stronger drugs (Metformin only atm) these family of drugs will not be my first choice.

 

[NicoleC1971]

They are trying to get these class of drugs approved for type 1 diabs who have a large post prandial spike in glucose but it will be contraindicated for those with a history of getting into ketoacidosis easily...
In my 36 year 'career' this has only happened to me twice? And I have had some hideously high blood sugars.
I was interested because this class of drugs gets you to expel glucose via the kidneys in tpe 2s and in type 1 inhibits the take up of glucose into the blood plus they are linked to an improvement in renal and cardiovascular outcomes.
However I would very much prefer not to need them and get my HBA1c down using my new toy (freestyle libre)!

 

[Irene Banting]

The link is in relation to an alert about this class of drug causing a rare and serious genital infection called necrotising fasciitis of the perineum, not about the usual action of the medication. It sounds awful, and really strange. I have never heard of such a thing before!

 

[Guzzler]

The link is in relation to an alert about this class of drug causing a rare and serious genital infection called necrotising fasciitis of the perineum, not about the usual action of the medication. It sounds awful, and really strange. I have never heard of such a thing before!

This has also been reported here on the forum.

 

[Indy51]

The main thread for these reports is this one:
https://www.diabetes.co.uk/forum/th...-on-the-risk-of-diabetic-ketoacidosis.104325/