TokSik said:
Research on cannabis and cannabinoids related to diabetes:
Cannabidiol Preserves Retinal Neurons and Reduces Vascular Permeability in Experimental Diabetes (abst - 2004)
http://abstracts.iovs.org/cgi/content/a ... type=HWCIT
The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats.
(abst – 2004) http://www.ncbi.nlm.nih.gov/pubmed/15519750
Cannabidiol lowers incidence of diabetes in non-obese diabetic mice (full - 2005) http://www.ncbi.nlm.nih.gov/pmc/article ... =pmcentrez
Activation of the Peripheral Endocannabinoid System in Human Obesity
(full - 2005) http://www.ncbi.nlm.nih.gov/pmc/article ... =pmcentrez
Gpr40 Gene Expression in Human Pancreas and Insulinoma. (abst – 2005)
http://www.ncbi.nlm.nih.gov/pubmed/16289108
The Ffa Receptor Gpr40 Links Hyperinsulinemia, Hepatic Steatosis, and Impaired Glucose Homeostasis in Mouse. (abst – 2005)
http://www.ncbi.nlm.nih.gov/pubmed/16054069
Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes (full - 2006) http://www.ncbi.nlm.nih.gov/pmc/article ... ool=pubmed
Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and ß-Pancreatic Cells and in Obesity and Hyperglycemia (full - 2006)
http://jcem.endojournals.org/cgi/conten ... eb61349982
Weight Control in Individuals With Diabetes (full - 2006)
http://care.diabetesjournals.org/conten ... type=HWCIT
415
Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/17011761
Expression of the Gene for a Membrane-bound Fatty Acid Receptor in the Pancreas and Islet Cell Tumours in Humans: Evidence for Gpr40 Expression in Pancreatic Beta Cells and Implications for Insulin Secretion. (abst – 2006)
http://www.ncbi.nlm.nih.gov/pubmed/16525841
The Cannabinergic System as a Target for Anti-inflammatory Therapies
(abst - 2006) http://www.ingentaconnect.com/content/b ... 3/art00008
Non-Psychoactive Cannabinoid Reduces Incidence Of Diabetes, Study Says
(news - 2006) http://www.norml.org/index.cfm?Group_ID=6909
Marijuana Compound May Help Stop Diabetic Retinopathy (news - 2006)
http://www.sciencedaily.com/releases/20 ... 184647.htm
Cannabidiol, a marijuana compound, may help stop diabetic retinopathy (news – 2006)
http://www.xagena.it/news/medicinenews_ ... b6f17.html
Marijuana Compound Offers Hope In Diabetic Retinopathy Prevention (news – 2006)
http://www.bio-medicine.org/medicine-ne ... on-8121-1/
Cannabidiol reduces the development of diabetes in an animal study (news - 2006)
http://www.cannabis-med.org/english/bul ... p?id=219#3
Getting Eye On Cannabinoids (news - 2006)
http://www.thehempire.com/index.php/can ... nnabinoids
Marijuana compound could prevent eye damage in diabetics (news - 2006)
http://www.thehempire.com/index.php/can ... _diabetics
Compound found in marijuana may defend against diabetic retinopathy (news – 2006)
http://www.news-medical.net/news/2006/03/01/16284.aspx
Cannabidiol arrests onset of autoimmune diabetes in NOD mice (full - 2007)
http://safeaccess.ca/research/pdf/Weiss ... gy2007.pdf
Expression of Cannabinoid CB1 Receptors in Models of Diabetic Neuropathy
(full - 2007)
http://jpet.aspetjournals.org/content/3 ... type=HWCIT
Cannabidiol attenuates high-induced endothelial cell inflammatory response and barrier disruption (full - 2007) http://www.pubmedcentral.nih.gov/articl ... =pmcentrez
416
US Patent Application 20070099987 - Treating or preventing diabetes with cannabidiol
(full – 2007) http://www.patentstorm.us/applications/ ... ltext.html
Role of cannabinoid CB2 receptors in glucose homeostasis in rats (abst – 2007)
http://www.sciencedirect.com/science/ar ... 990700249X
The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells (abst - 2007) http://lib.bioinfo.pl/pmid:17604177
Anticoagulant Effects of a Cannabis Extract in an Obese Rat Model (abst - 2007)
http://marijuana.researchtoday.net/archive/4/4/736.htm
Mediation of Cannabidiol anti-inflammation in the Retina by Equilibrative Nucleoside Transporter and A2A Adenosine Receptor (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/article ... =pmcentrez
The Role of Adipocyte Insulin Resistance in the Pathogenesis of Obesity-Related Elevations in Endocannabinoids (full – 2008)
http://diabetes.diabetesjournals.org/co ... 50931c5e25
GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/article ... =pmcentrez
Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. (full – 2008)
http://www.ncbi.nlm.nih.gov/pmc/article ... ool=pubmed
Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High-fat Diet (full - 2008) http://www.nature.com/oby/journal/v16/n ... 7106a.html
Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation. (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/article ... ool=pubmed
Endocannabinoids and the Control of Energy Homeostasis (full – 2008)
http://www.jbc.org/content/283/48/33021 ... d75bb49403
Mediation of Cannabidiol Anti-inflammation in the Retina by Equilibrative Nucleoside Transporter and A2A Adenosine Receptor (full – 2008) http://www.iovs.org/content/49/12/5526.full
Effect of anandamide in improving of the non-adrenergic non-cholinergic relaxation of the corpus cavernosum from diabetic rats (abst – 2008) http://www.doaj.org/doaj?func=abstract& ... anguage=en
417
Presence of functional cannabinoid receptors in human endocrine pancreas.
(abst – 2008) http://www.ncbi.nlm.nih.gov/pubmed/18092149
Cannabidiol As a Putative Novel Therapy for Diabetic Retinopathy: A Postulated Mechanism of Action as an Entry Point for Biomarker-Guided Clinical Development. (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/article ... ool=pubmed
Cannabinoids as novel anti-inflammatory drugs. (full - 2009)
http://www.ncbi.nlm.nih.gov/pmc/article ... ool=pubmed
Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/article ... ool=pubmed
The endocanabinnoid system and diabetes - critical analyses of studies conducted with rimonabant (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/article ... =pmcentrez
Biological effects of THC and a lipophilic cannabis extract on normal and insulin resistant 3T3-L1 adipocytes (abst - 2009)
http://www.unboundmedicine.com/medline/ ... dipocytes_
Anti-inflammatory effect of palmitoylethanolamide on human adipocytes. (abst – 2009)
http://www.ncbi.nlm.nih.gov/pubmed/19131941
Beneficial effects of a Cannabis sativa extract on diabetes induced neuropathy and oxidative stress. (abst - 2009)
http://www.unboundmedicine.com/medline/ ... ve_stress_
Cannabis plant extracts could potentially form the basic ingredients for a market-leading diabetes drug (news – 2009)
http://www.thefreelibrary.com/Cannabis+ ... 0202701009
Medical Marijuana and Diabetes, Adult Onset (news – 2009)
https://www.marijuanadoctors.com/conten ... dult-onset
Expression and function of cannabinoid receptors in mouse islets. (full – 2010)
http://www.landesbioscience.com/journal ... ETS2-5.pdf
Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain (full - 2010)
http://www.ncbi.nlm.nih.gov/pmc/article ... =pmcentrez
Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/article ... ool=pubmed
418
Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy (full – 2010)
http://diabetes.diabetesjournals.org/co ... ec5dfac384
Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. (full – 2010)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003779/
Cannabinoid Receptors are Coupled to Stimulation of Insulin Secretion from Mouse MIN6 β-cells (full – 2010)
http://content.karger.com/ProdukteDB/pr ... 320527.pdf
Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients (full - 2010) http://www.lipidworld.com/content/9/1/43
Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white adipose tissue, muscle, and liver: the role of eNOS, p38 MAPK, and AMPK pathways.
(full – 2010) http://diabetes.diabetesjournals.org/co ... ong#sec-25
Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes. (full - 2010) http://www.ncbi.nlm.nih.gov/pmc/article ... ool=pubmed
Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy
(full - 2010) http://www.natap.org/2010/newsUpdates/marijuana.pdf
Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes? (full – 2010) http://www.jci.org/articles/view/44099?search[abstract_text]=&search[article_text]=cannabinoid&search[authors_text]=&search[fpage]=&search[title_text]=&search[volume]=
Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients. (full – 2010)
http://www.ncbi.nlm.nih.gov/pmc/article ... ool=pubmed
Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation.
(full– 2010) http://www.wjgnet.com/1948-9358/full/v1/i1/12.htm
Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20937249
AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20816753
419
Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age. (abst – 2010) http://www.springerlink.com/content/g037q1lh40l15161/
Endocannabinoid (EC) Receptor, CB1, and EC Enzymes' Expression in Primary Adipocyte Cultures of Lean and Obese Pre-pubertal Children in Relation to Adiponectin and Insulin (abst – 2010)
http://www.degruyter.com/abstract/j/jpe ... annabinoid
G1359A polymorphism in the cannabinoid receptor-1 gene is associated with metabolic syndrome in the Chinese Han population. (abst – 2010)
http://www.ncbi.nlm.nih.gov/pubmed/20851297
GPR119 agonists for the potential treatment of type 2 diabetes and related metabolic disorders. (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/21094910
Pot Compound Mitigates Diabetic Cardiomyopathy (news - 2010)
http://www.norml.org/index.cfm?Group_ID=8424
Cannabinoids inhibit and may prevent neuropathic pain in diabetes. (news - 2010)
http://medigardens.blogspot.com/2010/04 ... d-may.html
Lab Notes: Pot Has Benefits for Diabetic Hearts (news - 2010)
http://www.medpagetoday.com/LabNotes/LabNotes/23853
A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans.
(full – 2011) http://joe.endocrinology-journals.org/c ... 2/177.long
Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161308/
Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice (full– 2011)
http://www.ncbi.nlm.nih.gov/pmc/article ... ool=pubmed
Role for cannabinoid receptors in human proximal tubular hypertrophy. (full– 2011)
http://content.karger.com/produktedb/pr ... 97&typ=pdf
The association of the rs1049353 polymorphism of the CNR1 gene with hypoadiponectinemia. (full – 2011) http://www.rjme.ro/RJME/resources/files ... 791795.pdf
Central Endocannabinoid Signaling Regulates Hepatic Glucose Production and Systemic Lipolysis (abst – 2011) http://diabetes.diabetesjournals.org/co ... 5.abstract
Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells (abst – 2011)
http://diabetes.diabetesjournals.org/co ... ec5dfac384
420
Acute cannabinoid receptor type 1 (CB1R) modulation influences insulin sensitivity by an effect outside the central nervous system in mice. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21340622
Cannabinoid receptor agonists and antagonists stimulate insulin secretion from isolated human islets of Langerhans. (abst – 2011)
http://www.unboundmedicine.com/medline/ ... angerhans_
Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes. (abst – 2011)
http://www.unboundmedicine.com/medline/ ... _Diabetes_
Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21238581
Win 55,212-2 reduces cardiac ischaemia-reperfusion injury in zucker diabetic fatty rats: role of cb2 receptors and cardiac inos/enos expression. (abst – 2011)
http://www.unboundmedicine.com/medline/ ... xpression_
GPR119 Regulates Murine Glucose Homeostasis Through Incretin Receptor-Dependent and Independent Mechanisms (abst – 2011)
http://endo.endojournals.org/content/15 ... a533824b24
Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease. (abst – 2011)
http://www.ncbi.nlm.nih.gov/pubmed/21633404
Cannabidiol Dampens Streptozotocin-Induced Retinal Inflammation by Targeting of Microglial Activation (abst - 2011)
http://abstracts.iovs.org/cgi/content/a ... type=HWCIT
The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/22029844
The Endocannabinoid System: Plant-Derived Cannabinoids in Diabetes and Diabetic Complications. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/22155112
TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21752941
Takeda moves potential first-in-class diabetes drug into phase III (news – 2011)
http://www.inpharm.com/news/166980/take ... -phase-iii
421
Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III. (full – 2012)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289985/
The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119. (full - 2012)
http://onlinelibrary.wiley.com/doi/10.1 ... 755.x/full
The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity.
(full – 2012) http://diabetes.diabetesjournals.org/co ... 2/281.long
Endocannabinoids measurement in human saliva as potential biomarker of obesity.
(full – 2012) http://www.ncbi.nlm.nih.gov/pmc/article ... ool=pubmed
Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series (full – 2012)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500919/
Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids, Oxylipins and Endocannabinoids (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493609/
Excess of the endocannabinoid anandamide during lactation induces overweight, fat accumulation and insulin resistance in adult mice (full – 2012)
http://www.dmsjournal.com/content/4/1/35
Relationships between glucose, energy intake and dietary composition in obese adults with type 2 diabetes receiving the cannabinoid 1 (CB1) receptor antagonist, rimonabant
(full – 2012) http://www.nutritionj.com/content/11/1/50
Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372498/
Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice (full – 2012) http://www.lipidworld.com/content/11/1/98
Islet protection and amelioration of diabetes type 2 in Psammomys obesus by treatment with cannabidiol (link to PDF - 2012)
http://www.scirp.org/journal/PaperInfor ... erID=17302
Characterization of cannabinoid-induced relief of neuropathic pain in rat models of type 1 and type 2 diabetes. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22609797
Overexpression of cannabinoid CB2 receptor in the brain induces hyperglycaemia and a lean phenotype in adult mice. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22487302
422
Induction of Glucose Intolerance by Acute Administration of Rimonabant.
(abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22678147
TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. (abst – 2012)
http://www.ncbi.nlm.nih.gov/pubmed/22374408
Stimulating beta cell replication and improving islet graft function by GPR119 agonists.
(abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21902730
A Randomized, Double-Blind, Placebo Controlled, Parallel Assignment, Flexible Dose, Efficacy Study of Nabilone as Adjuvant in the Treatment of Diabetic Peripheral Neuropathic Pain Using an Enriched Enrollment Randomized Withdrawal Design (S38.003) (abst – 2012) http://www.neurology.org/cgi/content/me ... type=HWCIT
The Novel Reversible Fatty Acid Amide Hydrolase Inhibitor ST4070 Increases Endocannabinoid Brain Levels and Counteracts Neuropathic Pain in Different Animal Models (abst – 2012)
http://jpet.aspetjournals.org/content/3 ... bb89fd59f5
G1359A polymorphism in the cannabinoid receptor-1 gene is associated with the presence of coronary artery disease in patients with type 2 diabetes. (abst – 2012)
http://www.ncbi.nlm.nih.gov/pubmed/22138970
A Multiple-Ascending-Dose Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of a Novel GPR40 Agonist, TAK-875, in Subjects With Type 2 Diabetes. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22669289
Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent. (abst – 2012)
http://www.ncbi.nlm.nih.gov/pubmed/22490067
An enriched-enrolment, randomized withdrawal, flexible-dose, double-blind, placebo-controlled, parallel assignment efficacy study of nabilone as adjuvant in the treatment of diabetic peripheral neuropathic pain. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22921260
The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: potential implications for the treatment of obesity. (abst – 2012)
http://www.ncbi.nlm.nih.gov/pubmed/22943701
Reports of the death of CB1 antagonists have been greatly exaggerated: recent preclinical findings predict improved safety in the treatment of obesity. (abst – 2012)
http://www.ncbi.nlm.nih.gov/pubmed/22743603
423
Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats.
(abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22959964
New vistas for treatment of obesity and diabetes? Endocannabinoid signalling and metabolism in the modulation of energy balance. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22674489
Chronic activation of cannabinoid receptors in vitro does not compromise mouse islet function. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/23078523
The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: potential implications for the treatment of obesity (abst – 2012) http://onlinelibrary.wiley.com/doi/10.1 ... x/abstract
Synthetic cannabinoid could treat pain in diabetes patients (news – 2012)
http://www.medwirenews.com/57/102248/Di ... ents_.html
Study: Synthetic THC Analogue Mitigates Diabetic Neuropathy, Is 'Well Tolerated' In Patients (news – 2012)
http://norml.org/news/2012/09/20/study- ... n-patients
New drug offers novel pain management therapy for diabetics. (news - 2012)
http://www.thefreelibrary.com/New+drug+ ... 0306899453
Drug offers new pain management therapy for diabetics (news – 2012)
http://medicalxpress.com/news/2012-10-d ... etics.html
Is the cardiovascular system a therapeutic target for cannabidiol? (abst – 2013)
http://onlinelibrary.wiley.com/doi/10.1 ... x/abstract
Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids (abst – 2013) http://www.nature.com/neuro/journal/vao ... .3321.html
