Recent Content by wu-lee

  1. W

    How Metformin works, AKA "Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides"

    No particular point - or not yet, maybe after investigating further, but that'll take a while. I am not a biochemist. Possibly someone else may have an interesting comment. Following the research can be helpful when attempting to fact check some of the claims made about diabetes. (And for...
  2. W

    How Metformin works, AKA "Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides"

    My partner is an academic developmental biologist, and came across this paper on the mechanism of metformin. https://www.science.org/doi/10.1126/science.ade3332 She says: She adds: However, she found this Twitter thread which puts it into context and gives a summary of current thinking -...
  3. W

    Where can you get a Kraft Test in the UK?

    As I understand it these are two different things? - Glucose clamp: fix the blood glucose using a computer controlled drip feed, measure insulin - Kraft test: following fasting, administer a fixed oral dose of glucose, then periodically measure blood insulin and glucose over several hours So...
  4. W

    Where can you get a Kraft Test in the UK?

    That's exactly the question I asked when I was diagnosed. As I mentioned, the earlier answer to "Which is it, a) or b)?" was "Well, we could measure your insulin, but we're not going to do that", and to my later question "Why not?" amounts to "Because it doesn't make any difference." I...
  5. W

    Where can you get a Kraft Test in the UK?

    The only update I have is that I got an appointment to see the endocrinologist at the diabetic clinic at the Edinburgh Royal Infirmary, and amongst other things, asked him why I'd never had my insulin measured, despite having a glucose tolerance test. I also asked whether he knew about the Kraft...
  6. W

    Where can you get a Kraft Test in the UK?

    Thanks! Selected locations in the UK, nothing in Scotland unfortunately. Quite expensive at £350, too. But it's something.
  7. W

    Where can you get a Kraft Test in the UK?

    Thanks for this - another avenue for investigation! I'd never heard of this. Is there any source you know of explaining why ketones would serve as a proxy for insulin? Searching for Angela Stanton and the Kraft test I find this, which explains the process somewhat, but not why it works...
  8. W

    Second-hand or shared continuous glucose monitors?

    Thanks, clarified with an edit. In the light of this perhaps the question is finding a CGM/FGM which has cheaper consumables. Although I can probably afford £50 for the odd fortnight.
  9. W

    Second-hand or shared continuous glucose monitors?

    Yes, I do understand this point, I'm not suggesting these sensors would be re-used. I know this doesn't address the cost of the sensors. [edit] Ah, I think what you're telling me is that there is no separate monitor device, the sensors are all there is to the package?
  10. W

    Second-hand or shared continuous glucose monitors?

    As a Type-2, managing my condition through diet alone, and having read Jenny Ruhl's "Diabetes 101", I'm concerned that post-meal blood spikes are the thing to watch. I check these with a cheap SD Code-free glucometer. This is adequate. Nevertheless, I can't see what happens between meals, or...
  11. W

    Where can you get a Kraft Test in the UK?

    This is the reply from Medicheck about their insulin resistance test. TLDR: it's just a fasting insulin measurement for which you need to physically attend their lab in London.
  12. W

    Where can you get a Kraft Test in the UK?

    Thanks all. I see now this question has been asked before, for instance: https://www.diabetes.co.uk/forum/threads/insulin-testing-which-tests-on-the-nhs.128969/ It's a little unclear from that what is what. And there is quite a range of prices! £450 from Blood.London down to £69 from...
  13. W

    Have you been told not to test your blood sugars?

    Thank you for that. It answers one of my outstanding questions: "Where does my doctor get their information?" However I noticed the link is broken already... Reading your earlier link to the full guidelines, I see it now says: This may be why it has gone. I'm not sure what the replacement...
  14. W

    Where can you get a Calcium Score (AKA Agaston) test in the UK?

    Thanks - slow reply, sorry. I looked PREDICT up, interesting, sounds like exactly the thing I'd like to join, and it seems it has something to do with Tim Spector. But I couldn't find any way to participate. In fact their twitter feed says the study is concluded? (Can't include a link, as I've...
  15. W

    Where can you get a Kraft Test in the UK?

    Thanks. The glucose tolerance test also needs a 3 to 5 hour follow up, and I *did* get one of those a few years ago from the NHS diabetic specialist clinic I was attending (which involved me waiting around, not so much them.) So I think there must be more behind the reason than the duration. I...