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I've only been on dapagliflozin (Forxiga) as part of a dual medication pill (Xigduo) for five weeks so I'm no expert. I've never had sudden urges to pee since I started it though that may be because it is my long time habit to drink lots of water. I rarely feel that sudden 'need to pee' urge...

This is worth a read if you have the time to wade through it: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579902/ Beyond the immediate effects on BG levels while engaged in exercise (which others have rightly stated may be associated with adrenaline levels and what you're eating before and...

Extremely interesting and informative, thank you very much for this. It's given me much food for thought.

Very informative, thank you. BTW there's a bug in 'Hugh's calculator' in that it uses the Friedewald equation (1972) to calculate LDL, but allows very high triglyceride levels to be input. That equation doesn't work if triglyceride levels are too high. On a standard lipid panel LDL isn't...

Hi there, Without offering medical advice, here is a list of links to information that I currently trust to guide me on the matter of cholesterol. Heart UK, 'The cholesterol charity', 'Understanding your cholesterol results'...

To clarify this point, unexpected weight loss is a symptom of both Type 1 and Type 2 diabetes. The weight loss is caused by uncontrolled, very high blood glucose levels, which causes the body to dump excess glucose via the urine. You pee calories. While diagnosis of Type 2 is typically...

I don't have the knowledge to respond to much in your post other than this, and we are not allowed to offer medical advice on this forum. We are allowed to speak from personal experience however, so I can say that shortly after I started Metformin I experienced greatly lowered libido for a...

Down 1.35Kg on the week (around 3lbs). Trying to target 1Kg per week at present. Attached a screenshot from the app that comes with my smart scale (Made by Renpho, currently £17.50 on Amazon UK if anyone is interested in gadgets). I weigh myself first thing in the morning after using the...

Ahhhh... I see what you did there. There was a time not so long ago, before the media went wild about conspiracy theories, when googling 'evidence that the earth is flat' would get you some interesting results. Evidence. You can still see the effect though if you know what to search for. Try...

Your Google must work differently to my Google. When I search either 'does omega 6 increase cardiovascular risk' or 'does omega 6 decrease cardiovascular risk' I get the same kinds of results, all of which appear to contradict the notion that Omega 6, when eaten in moderation, causes any harm...

This seems like a good place to post this - a long interview with Prof. Roy Taylor covering his 'Twin Cycle Hypothesis' as the root cause of Type 2, his (I think it's his?) 'Personal Fat Threshold' theory, the role of genetics, and lots of other interesting stuff. I'm not sure I agree with...

Is there any chance, maybe, just maybe, Type 2 diabetes may also occur when the pancreas is no longer able to produce enough insulin without being prodded with medication? Or not even then, requiring insulin injections? The whole beta cell damage thing?

Wow. It really is astonishing how little I know about Type 2 diabetes. I clearly have a lot more reading to do. So, a Type 2 diabetic has high circulating insulin levels? I assume then, when a doctor prescribes sulfonylureas, or a GLP1 agonist, or plain old insulin injections, the doctor is...

On the 'inflammation, oxidative stress, endothelial dysfunction and atherosclerosis' thing I'd appreciate a few links to good info along these lines, if you have any handy. It's a topic I've become curious about. On the calories in/calories out thing - everything we put in our mouths must be...

The calorie burn figures were not accurate in my case. My suspicion is that a person has to be relatively close to the average level of cardiovascular fitness in order for their calorie burn figures to be close to accurate, as their figures are calculated based on heart rate, but that's just a...

Sounds like a pretty good ethos to me. Written in language that does not sway the reader toward any particular competing viewpoint, includes references to all competing viewpoints, and does not favour one viewpoint over another via the quantity or quality of swaying statements or references...

Some excellent posts and a couple of highly illustrative examples made on this thread. Many thanks to all for taking the time to respond. On the point above about Wikipedia it should be noted that anyone can make changes to a Wikipedia page. When a change is proposed you have to do a bit of...

There are conspiracies, which do indeed exist in this world, and there are conspiracy theories. One darkly hilarious QAnon one, to take just one of hundreds of examples, is that the ship that blocked the Suez canal a few years ago was carrying containers of people that were being trafficked by...

Confirmation bias, according to the Wikipedia definition, is the tendency to search for, interpret, favour, and recall information in a way that confirms or supports one's prior beliefs or values. https://en.wikipedia.org/wiki/Confirmation_bias It is a universal aspect of human reasoning and...

Very many thanks. A very good summary of the side effects, risks and potential benefits. I do wonder though if the longevity thing is more a result of long lasting lifestyle changes following diagnosis than it is due to the effects of the drug itself.