Yes, I was able to cope with one tablet of ordinary metformin but at three my body rebelled. I spoke to my doctor who changed my prescription to Metformin MR twice a day. I seem better able to cope with this formulation though it still "makes its presence felt" occasionally. Interestingly, I typically get these worse effects if I have a meal higher in carbs than normal (relatively, I eat less than 30g carbs each day, even when I have a "high" carb meal).I was recently put on metformin 500mg x1 tablet at teatime. It was okay. No drastic chaos accept regular bottom burps! LOL! Then dosage up to 2 tablets (extended release) 1000mg a day and CHAOS! So changed myself back to 1 tablet per day. Anyone else suffer 'CHAOS' as result of dosage going up to two tablets a day?
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