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Abstract Biguanidos and vitamin B12

HICHAM_T2

Well-Known Member
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1,447
Location
Morocco
Type of diabetes
Type 2
Treatment type
Diet only
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Nothing
Abstract

Chronic metformin use results in vitamin B12 deficiency in 30% of patients. Exhaustion of vitamin B12 stores usually occurs after twelve to fifteen years of absolute vitamin B12 deficiency. Metformin has been available in the United States for approximately fifteen years. Vitamin B12 deficiency, which may present without anemia and as a peripheral neuropathy, is often misdiagnosed as diabetic neuropathy, although the clinical findings are usually different. Failure to diagnose the cause of the neuropathy will result in progression of central and/or peripheral neuronal damage which can be arrested but not reversed with vitamin B12 replacement. To my knowledge, this is the first report of metformin-induced vitamin B12 deficiency causing neuropathy.
Source https://www.ncbi.nlm.nih.gov/pubmed/20134380
 
I am a firm believer in using drugs in the short term, unless there is no other option, mainly due to the concentration amounts of whatever it is, the possible contra-indications and side effects.
 
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