Insulin Sensitivity Factor is not taken into account when you are in SmartGuard. It does it's own calculations every 24 hours to work out what it should be rather than using the ones set in delivery settings.
@Sasha1! I've found that when I'm high for a prolonged period of time, the pump will eventually stop giving corrections, I'm not entirely sure why that is, whether it's because it's reached a max amount it can give for the day or doesn't want to stack too much insulin.. if you're still high after a couple of hours I'd do a manual BG check and input that into the pump - you should then be able to press the down arrow and it should suggest giving more insulin as a 'manual' correction if you don't have insulin on board already. That should also 'reset' the pump and it should continue to give its own corrections after that