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Advice would be welcome

DaveW60

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3
Apologies if this is long, but I could use both advice and probably encouragement.

2020 started with a medical bang for me. On New Years Day, I started peeing blood. Straight to GP following morning to give urine sample, and later again same day for blood sample. There were communication issues at this point, as the next thing I knew was a call from the local hospital to rearrange my urgent urological cancer referral: I later realised the GP surgery was following NICE guidelines to the letter, but hadn't actually told me. After hospital visits for ultrasound, an inserted camera to check bladder, digital rectal exam and then for an MRI scan - and a long wait (4 weeks) for results - I was given an all clear. Small cyst on one kidney: lots of people have them, no need for concern. But...

I'd always been a frequent pee-er (and a frequent coffee drinker too - I've been cutting down since), so nocturnal peeing was discussed. It started over the previous year or so, although subsequent cutting back on fluid intake in the evening has helped. (I usually now sleep through till about 30 mins before the alarm clock.) It was a relief that my prostate and kidneys checked out fine (my father had cancer in both at different times), but I'm still peeing a fair bit some days. (Usually slightly more than average, sometimes more with bouts where I seem to pee every 30 mins for a while, usually late afternoon. This seems fairly variable from day to day.)

The blood tests, meanwhile, had flagged up high cholesterol (Total 8.8, HDL 1.9, Triglycerides 2.4, Non-HDL 6.9, Total/HDL ration 4.6, LDL 5.8). Appointment with nurse - the only person I've seen at the surgery, despite making appointments to see a doctor - to discuss, where I explained I hadn't really taken in the figures when first told as far too anxious re: possible cancer. Explained that I had made serious lifestyle changes (complete cold turkey on smoking, now exercising (brisk walking) about 60-90 mins 5-7 days a week, cutting calories, using a FitBit to track), and wanted to continue on that basis for a while to see if I could reduce numbers and come for second blood test. I had also reduced my blood pressure from 151 to 130 in about 5 weeks (early-Jan to mid-Feb): the nurse was both gobsmacked and full of praise at that.

The day before the appointment for new blood tests, my M-i-L passed away, and I cancelled the appointment to support my partner. And then we went into the March lockdown.

I've carried on with the new diet and exercise, and have shed 16kg (was 79, now 63), bringing my BMI down from 27.5 to 21.7. I've cut out nearly all baked goods (annoying: I'm an excellent baker) except oatbakes made with soy milk, flaxseed and blueberries and a vegan, sugar free apple crumble. I'm using sugar free, low carb oat or soy milks and yoghurts in both coffee (decaff only) and cooking, and eating oily fish about 3 times a week: meat only very occasionally. Eating lots of veg, some homegrown, beans, seeds, pulses. Generally, I'm feeling much fitter and healthier.

Many years of tending towards bloating, constipation and indigestion seem to have passed: I was told many years ago by an emergency doctor that an acute attack of constipation and cramping was probably IBS, and I've used mebeverine to address passing problems from time to time. Since February, I've had only one minor episode, resolved in 24 hours with senokot.

So why this posting?

I've noticed that as well as the fresh (fasting) blood test, the cancelled appointment also included a Plasma Glucose Test.

I've also noticed:
a) a couple of episodes of tingling/stinging in my hands (especially when in water) that a couple of days later stops tingling and turns into very dry skin - moisturising very frequently helps, and during the worst (first) episode, I slept with silk gloves on: this seemed to resolve the problem within 48 hours or so (and could be a reaction to more frequent handwashing and to hand sanitiser, which seems very drying, and it could be eczema-elated - I had psoriasis when younger, although this seems to have ceased)
b) about two weeks ago, after a longish walk in new boots, I noticed three toenails on one foot had turned purple: it looks like bruising under the nail, and one toe occasionally feels slightly bruised. There's no other pain, and I've not noticed any other particular feet issues - this *could* be new boots syndrome (they're now sitting in a corner with shoe trees in )
c) outbreaks of dry/itchy skin (usually chin) and being a frequent pee-er have been part of life for as long as I remember (certainly 40+ years with the skin), so that could be 'just me'
c) my new diet may be doing my wellbeing apparent good and my waistline a marvellous service (I have a whole 'new' wardrobe of clothes I've not worn in 7 or 8 years), but fitbit is showing we're typically eating about 55% carbs.

Obviously, I'm concerned these could be diabetes symptoms and I've not had a blood glucose test. So I should - if the surgery is allowing blood test appointment (when I looked in July, they weren't offering them at all) - attend and at least be informed. (I hope this community would be there with inevitable subsequent answers. I'm not as utterly anxious as I was in January/February with the cancer tests, but worries do tend to pray on me.)

What would you advise me to discuss with the surgery, and any other actions I might take/consider? I'm thinking that:

a) it seems statins - which I turned down at this stage - can raise blood sugars, so taking them might cause further issues
b) reducing carb intake seems to be widely recommended here, but in short term may increase cholesterol readings which may lead the surgery back to (a) and be insistent that I start statins/// thus leading back to (b). I'm also aware that many GP/surgery nurses have firm views that a patient can cause problems by querying: my reluctance on statins didn't go down well.

Sorry this is so long, and many thanks for reading.
 
Your bruised toes and black nails are probably caused by your toes either hitting the front of your boots as you walk, it often occurs whilst walking down hill, or by them hitting the top of your boot. They do not need to hit hard and you may not feel it they just need to hit often. So likely not a symptom of diabetes.
 
I had a raft of blood tests that diagnosed the diabetes and less than ideal cholesterol. I then started Low carb and lifestyle changes. Although I was given 3 monthly hb1ac I refused to consent to cholesterol testing for a year (ie the usual interval). Mostly as having done my research I was convinced I’d refuse statins anyway so the test was pointless and partly to avoid the arguments a temporary rise whilst losing weight would cause. If they didn’t have results they couldn’t try to demand statins. At my annual review cholesterol was much improved and stations not recommended despite being over a total of 4 by a fair bit - the ratios and “good” bits were excellent.
 
Get an hba1c to check but sounds like you resolved lots of your ailments just by cutting out gluten and/or carbs.
The reduction in weight and blood pressure are great because they are 2 symptoms of insulin resistance (something which can lead to type 2 diabetes). A poor ration of trigs/hdl (the former being greater than the latter) is another sign so would be interesting to see how that comes out and that should be measured when they do the hba1c (average blood glucose test).
The other things aren't something I'd associate with diabetes and am not a dematologist but if you think it is something you are in contact with the obvious thing would be to stop using whatever that is and see what happens. You can wash hands in a kind soap if you'd rather not use hand san!
Good luck and keep up the good work on the diet and walking front.
 
ps I personally would not take a statin as your ldl isn't a great indicator of risk of heart disease and you've already reduced your risk factors. There is an associated risk of type 2 diabetes in statin users but I can't quantify that.
 
Thanks everyone for answers so far, and for encouragement (very much appreciated right now).

A few remarks/clarifications:

  • I’ve avoided most gluten, but not carbs as yet (looking through Fitbit record, my diet is typically 50-55% carb (210-250g per day), which is possibly an increase on previous eating.) I’m looking to eat more fish/cheese/carb-less soy yoghurt/tofu to address this, but this seems to raise percentage of fat more than protein - although I’m being careful to minimise saturated fats as well as sugars. (I’m a hugely enthusiastic cook, always cooking from scratch: the year has seen a huge influx of veggie cookbooks, but if I need to rethink that, a culinary challenge is always welcome!) Using rapeseed and olive oils rather than butter for sauteing/dreesing.
  • Given my excursions this year are for walks and 10-5 mins a week in a supermarket for things we can’t get delivered (I’m not doing ‘indoors’ anywhere else that we don’t live), I’m not using hand san that often - generally if I have to touch anything while not at home - although it does feel very drying. Will try to moisturise hands more often, as that seems to help.
  • Not sure in the UK that hba1c is normally used to diagnose: it seems (from NICE website) that the usual method is, I think, called OGGT - blood glucose with 8 hour fasting. When I speak to surgery to try to re-arrange the missed appointment, I’ll see if I can ask/request.
  • I’ve also three times this year had an itchy rash just above my ankles: raised red spots which subside to flatter, red patches that don’t itch. Each time, it’s been less drastic than before (third incidence is now, and have 3 - 4 spots on each leg): like the hand issue, it seems to away of its own accord. Some evenings my feet ache, but I guess every 60 year old man says that? But daily walks of 7 - 10km are no problem at all.
Any more hints, tips or advice (or encouragement) very welcome.
 
Thanks everyone for answers so far, and for encouragement (very much appreciated right now).

A few remarks/clarifications:

  • I’ve avoided most gluten, but not carbs as yet (looking through Fitbit record, my diet is typically 50-55% carb (210-250g per day), which is possibly an increase on previous eating.) I’m looking to eat more fish/cheese/carb-less soy yoghurt/tofu to address this, but this seems to raise percentage of fat more than protein - although I’m being careful to minimise saturated fats as well as sugars. (I’m a hugely enthusiastic cook, always cooking from scratch: the year has seen a huge influx of veggie cookbooks, but if I need to rethink that, a culinary challenge is always welcome!) Using rapeseed and olive oils rather than butter for sauteing/dreesing.
  • Given my excursions this year are for walks and 10-5 mins a week in a supermarket for things we can’t get delivered (I’m not doing ‘indoors’ anywhere else that we don’t live), I’m not using hand san that often - generally if I have to touch anything while not at home - although it does feel very drying. Will try to moisturise hands more often, as that seems to help.
  • Not sure in the UK that hba1c is normally used to diagnose: it seems (from NICE website) that the usual method is, I think, called OGGT - blood glucose with 8 hour fasting. When I speak to surgery to try to re-arrange the missed appointment, I’ll see if I can ask/request.
  • I’ve also three times this year had an itchy rash just above my ankles: raised red spots which subside to flatter, red patches that don’t itch. Each time, it’s been less drastic than before (third incidence is now, and have 3 - 4 spots on each leg): like the hand issue, it seems to away of its own accord. Some evenings my feet ache, but I guess every 60 year old man says that? But daily walks of 7 - 10km are no problem at all.
Any more hints, tips or advice (or encouragement) very welcome.

In terms of your personal tolerances gluten may well be an issue but in terms of type 2 then carbs definitely are. Few of us doing low carb in here are concerned about saturated natural fats. There a huge amount of conflict about the typical advice relating to both saturated fats and cholesterol. An entire long thread dedicated to it too. In summary:most of us find that reducing carbs and processed fats bring our triglycerides down significantly and push our hdl up. Thus all important ratios are improved. Ldl is a bit more variable but tends to lower and if particle size is examined (rarely done) low carb makes the ldl large and boy at and so protective not damaging as opposed to small, dense and harmful.

Hb1ac is almost exclusively used to diagnose in the U.K. based on the experiences in here. OGTT was the old regime and not used much now.

Take a look at guttae psoriasis regarding the red spots. Ive had two bouts of this in the last couple of years. No idea if it’s diabetes or diet related mind. It was misdiagnosed a couple of times initially and for me definitely linked to a mild sore throat (strep?) and both times antibiotics sorted it when nothing else did. The first time took months of begging for it on my part despite nothing else working, some evidential support for it and being covered from neck to foot. Second time I got luckier and nipped it in the bud.
 
Wind forward a few months from my original message, my surgery opening up for blood tests again and giving in to the nagging doubt that I should get tested, I went back a few days ago.

(Qualms had not been helped by a friend contracting Covid in the local hospital and passing away as a result, and by very high infection rates locally until recently. Deep breath taken, surgery visited...)

I was additionally concerned by:
  • three outbreaks of itching/stinging on palms exacerbated by hot water, that tended to then lead to dry/flaking skin. Moisturising resolved it within a week or so each time it happened, and it could just be increased washing/sanitising. (GP prescribed cetraben last week, which I'm using: no problems at present)
  • chilblain like feelings in toes in February, though this has passed
  • moments of frequent peeing, mostly late afternoon, although that's been true for as many years as I can remember. (I'm on strictly decaff nowadays, and trying to stick to 6 - 7 a day, although old habits die hard. Usually only up once a night (I'm about to be 61, btw), and occasionally a little trickly then (as if my bladder's not always actually awake) but otherwise no problems with flow. PSA was tested last year (2.6) and DRE conducted during hospital tests during the cancer scare episode: no alarms raised, but presumably requesting a repeat now is non-controversial?
Fasting blood test results as follows:
  • Plasma fasting glucose level 5.4 mmol/L
  • Haemoglobin A1c level - IFCC standardised 31 mmol/mol [20.0 - 41.0]
I'm assuming from those figures that I'm not diabetic? (The first figure looks top of the range, but the second looks very 'normal' to my ignorant eyes.) I'm waiting on the surgery to arrange a follow-up phone call date to discuss results.

Cholesterols all improved too (previous figures in brackets):
  • Serum total cholesterol level 6.9 mmol/L (was 8.8)
  • Serum HDL cholesterol level 2.3 mmol/L (was 1.9)
  • NON-HDL CHOLESTEROL 4.6 mmol/L (was 6.9)
  • Serum cholesterol/HDL ratio 3.0 (was 4.6)
  • Serum triglyceride levels 0.9 mmol/L (was 2.4)
  • Calculated LDL cholesterol level 4.2 mmol/L (was 5.8)
These figures all seem to be fairly significantly improved (I was told last Jan that my chances of improving them with diet and exercise were improbable) although still high-ish: will they likely still suggest statins? (The online test record is marked Satsfactory/No Further Action.) And people's thoughts on possibly taking them be different if I'm not diabetic?

Until this week, I've been feeling mostly better than I have done in a long time: diet change (I cut back carbs to av. of about 120g pd last Nov, keep saturated fats low, eat a lot of oily fish/tofu for protein and go very light on starchy veg and grains: if diabetes is not a worry, I may relax a little there as I really don't need to lose any more weight), weight loss and exercise have presumably all helped. But I do get aches and pains in left shoulder and occasionally bicep from time to time, and currently have a phlegmy chesty cold (no other symptoms experienced, negative lateral flow test returned).

I am concerned to get my heart health checked, and guidance on what tests I can request would be welcome. (If you can get to a doctor at my surgery, they seem pretty good and responsive, but the gatekeeping and slot availability are formidable.) My FitBit tells me my heart health is excellent, but it's presumably just measuring pulse and recovery from exercise: hardly gospel. Qrisk3 calculates my risk as 9% - exactly normal for my age, apparently: BMI is now 20.7 (was 27.3) and BP 126/87 (was 135/88).

I appreciate no-one here can/will/should diagnose and I'm trying not to be The Anxious Well, but after a rollercoaster eighteen months it's difficult to be blithe. Husband also currently cathetered as having issues with BPH, so a tendency to fret being exacerbated by that, I suspect. Inputs and thoughts very welcome, and thank you all who responded last time around. Apologies for taking so long to challenge myself to get properly tested.
 
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